Pre-computed interfaces

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JET2 Viewer

Pre-computed interfaces from JET2

PDB Structure: 1BMR chain A sc2

 

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 Residue 
 Chain 
 Type 
 Evolutionary conservation
TJET 
 Physico-chemical properties
PC 
 Circular variance
CV 
 #detections 
1
A
VAL
0.32
0.56
0.77
10
2
A
ARG
0.58
0.51
0.59
10
3
A
ASP
0.85
0.32
0.60
10
4
A
GLY
0.87
0.41
0.37
10
5
A
TYR
1.00
0.80
0.36
10
8
A
GLN
0.45
0.43
0.45
2
9
A
PRO
0.49
0.47
0.52
7
10
A
GLU
0.35
0.33
0.64
3
11
A
ASN
0.96
0.39
0.58
3
12
A
CYS
1.00
0.64
0.42
3
13
A
VAL
0.84
0.56
0.33
9
14
A
TYR
0.69
0.80
0.33
10
15
A
HIS
0.57
0.60
0.55
10
16
A
CYS
1.00
0.64
0.53
10
17
A
PHE
0.29
1.00
0.72
10
18
A
PRO
0.49
0.47
0.76
10
19
A
GLY
0.36
0.41
0.73
10
20
A
SER
0.56
0.36
0.72
10
21
A
SER
0.25
0.36
0.77
10
22
A
GLY
0.59
0.41
0.64
10
23
A
CYS
1.00
0.64
0.40
10
24
A
ASP
0.69
0.32
0.58
2
25
A
THR
0.41
0.33
0.69
10
26
A
LEU
0.81
0.70
0.52
10
28
A
LYS
0.67
0.25
0.72
8
29
A
GLU
0.51
0.33
0.69
10
31
A
GLY
0.85
0.41
0.63
10
32
A
GLY
0.76
0.41
0.55
2
33
A
THR
0.43
0.33
0.74
10
34
A
SER
0.67
0.36
0.65
10
35
A
GLY
1.00
0.41
0.50
10
36
A
HIS
0.88
0.60
0.58
10
37
A
CYS
0.95
0.64
0.52
10
38
A
GLY
0.55
0.41
0.49
10
39
A
PHE
0.60
1.00
0.66
10
41
A
VAL
0.45
0.56
0.75
10
42
A
GLY
0.34
0.41
0.73
6
43
A
HIS
0.66
0.60
0.56
7
44
A
GLY
0.79
0.41
0.61
8
45
A
LEU
0.68
0.70
0.60
10
48
A
TRP
0.80
0.99
0.42
10
50
A
ASN
0.60
0.39
0.59
10
51
A
ALA
0.62
0.38
0.66
10
53
A
PRO
0.98
0.47
0.69
10
54
A
ASP
0.73
0.32
0.76
10
55
A
ASN
0.40
0.39
0.74
10
56
A
VAL
0.76
0.56
0.51
10
57
A
GLY
0.64
0.41
0.45
5
58
A
ILE
0.66
0.64
0.29
10
59
A
ILE
0.66
0.64
0.28
6
60
A
VAL
0.50
0.56
0.58
3
61
A
GLU
0.52
0.33
0.71
3
62
A
GLY
0.75
0.41
0.81
3
63
A
GLU
0.70
0.33
0.80
3
64
A
LYS
0.71
0.25
0.78
3
65
A
CYS
0.83
0.64
0.67
3
66
A
HIS
0.57
0.60
0.77
3
67
A
SER
0.16
0.36
0.76
3
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.58
10
3
A
ASP
0.85
0.32
0.60
10
4
A
GLY
0.87
0.41
0.35
10
5
A
TYR
1.00
0.80
0.32
10
8
A
GLN
0.45
0.43
0.46
3
9
A
PRO
0.49
0.47
0.51
9
10
A
GLU
0.35
0.33
0.65
3
11
A
ASN
0.96
0.39
0.56
3
12
A
CYS
1.00
0.64
0.40
3
13
A
VAL
0.84
0.56
0.32
6
14
A
TYR
0.69
0.80
0.30
10
15
A
HIS
0.57
0.60
0.56
10
17
A
PHE
0.29
1.00
0.70
10
18
A
PRO
0.49
0.47
0.75
10
19
A
GLY
0.36
0.41
0.77
10
20
A
SER
0.56
0.36
0.66
10
21
A
SER
0.25
0.36
0.77
10
22
A
GLY
0.59
0.41
0.67
10
24
A
ASP
0.69
0.32
0.57
9
25
A
THR
0.41
0.33
0.69
10
26
A
LEU
0.81
0.70
0.51
10
28
A
LYS
0.67
0.25
0.67
10
29
A
GLU
0.51
0.33
0.69
10
30
A
LYS
0.44
0.25
0.54
5
31
A
GLY
0.85
0.41
0.63
10
33
A
THR
0.43
0.33
0.73
10
34
A
SER
0.67
0.36
0.67
10
35
A
GLY
1.00
0.41
0.54
10
36
A
HIS
0.88
0.60
0.58
10
37
A
CYS
0.95
0.64
0.48
10
38
A
GLY
0.55
0.41
0.52
10
39
A
PHE
0.60
1.00
0.67
10
41
A
VAL
0.45
0.56
0.75
10
42
A
GLY
0.34
0.41
0.72
7
43
A
HIS
0.66
0.60
0.57
7
44
A
GLY
0.79
0.41
0.59
7
45
A
LEU
0.68
0.70
0.59
10
48
A
TRP
0.80
0.99
0.41
10
50
A
ASN
0.60
0.39
0.60
10
51
A
ALA
0.62
0.38
0.66
10
53
A
PRO
0.98
0.47
0.70
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.75
10
56
A
VAL
0.76
0.56
0.52
10
57
A
GLY
0.64
0.41
0.45
5
58
A
ILE
0.66
0.64
0.26
8
59
A
ILE
0.66
0.64
0.26
8
60
A
VAL
0.50
0.56
0.55
3
61
A
GLU
0.52
0.33
0.72
3
62
A
GLY
0.75
0.41
0.63
3
63
A
GLU
0.70
0.33
0.79
3
64
A
LYS
0.71
0.25
0.79
3
65
A
CYS
0.83
0.64
0.66
3
66
A
HIS
0.57
0.60
0.77
3
67
A
SER
0.16
0.36
0.76
3
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.58
10
3
A
ASP
0.85
0.32
0.61
10
4
A
GLY
0.87
0.41
0.38
10
5
A
TYR
1.00
0.80
0.38
10
8
A
GLN
0.45
0.43
0.42
5
9
A
PRO
0.49
0.47
0.47
6
10
A
GLU
0.35
0.33
0.59
4
12
A
CYS
1.00
0.64
0.44
10
13
A
VAL
0.84
0.56
0.38
10
14
A
TYR
0.69
0.80
0.34
10
15
A
HIS
0.57
0.60
0.56
10
17
A
PHE
0.29
1.00
0.72
10
18
A
PRO
0.49
0.47
0.78
10
19
A
GLY
0.36
0.41
0.75
10
20
A
SER
0.56
0.36
0.73
10
21
A
SER
0.25
0.36
0.77
10
22
A
GLY
0.59
0.41
0.63
10
24
A
ASP
0.69
0.32
0.63
9
25
A
THR
0.41
0.33
0.69
8
26
A
LEU
0.81
0.70
0.47
10
28
A
LYS
0.67
0.25
0.73
9
29
A
GLU
0.51
0.33
0.68
10
30
A
LYS
0.44
0.25
0.53
3
31
A
GLY
0.85
0.41
0.60
10
32
A
GLY
0.76
0.41
0.53
6
33
A
THR
0.43
0.33
0.71
9
34
A
SER
0.67
0.36
0.65
10
36
A
HIS
0.88
0.60
0.61
10
37
A
CYS
0.95
0.64
0.54
10
38
A
GLY
0.55
0.41
0.58
10
39
A
PHE
0.60
1.00
0.68
10
40
A
LYS
0.29
0.25
0.58
10
41
A
VAL
0.45
0.56
0.77
9
42
A
GLY
0.34
0.41
0.75
9
43
A
HIS
0.66
0.60
0.61
10
44
A
GLY
0.79
0.41
0.62
10
45
A
LEU
0.68
0.70
0.60
10
48
A
TRP
0.80
0.99
0.46
10
50
A
ASN
0.60
0.39
0.62
10
51
A
ALA
0.62
0.38
0.59
6
53
A
PRO
0.98
0.47
0.67
10
54
A
ASP
0.73
0.32
0.74
10
55
A
ASN
0.40
0.39
0.73
10
56
A
VAL
0.76
0.56
0.47
10
58
A
ILE
0.66
0.64
0.32
7
60
A
VAL
0.50
0.56
0.61
10
61
A
GLU
0.52
0.33
0.66
7
62
A
GLY
0.75
0.41
0.79
10
63
A
GLU
0.70
0.33
0.75
10
64
A
LYS
0.71
0.25
0.81
10
65
A
CYS
0.83
0.64
0.68
10
66
A
HIS
0.57
0.60
0.76
10
67
A
SER
0.16
0.36
0.72
10
1
A
VAL
0.32
0.56
0.77
10
2
A
ARG
0.58
0.51
0.59
10
3
A
ASP
0.85
0.32
0.60
10
4
A
GLY
0.87
0.41
0.35
10
5
A
TYR
1.00
0.80
0.34
10
8
A
GLN
0.45
0.43
0.43
5
9
A
PRO
0.49
0.47
0.52
9
10
A
GLU
0.35
0.33
0.61
7
11
A
ASN
0.96
0.39
0.54
8
13
A
VAL
0.84
0.56
0.35
10
14
A
TYR
0.69
0.80
0.35
10
15
A
HIS
0.57
0.60
0.57
10
17
A
PHE
0.29
1.00
0.73
10
18
A
PRO
0.49
0.47
0.77
10
19
A
GLY
0.36
0.41
0.74
10
20
A
SER
0.56
0.36
0.72
10
21
A
SER
0.25
0.36
0.76
10
22
A
GLY
0.59
0.41
0.63
10
24
A
ASP
0.69
0.32
0.60
10
25
A
THR
0.41
0.33
0.69
10
26
A
LEU
0.81
0.70
0.49
10
28
A
LYS
0.67
0.25
0.70
10
29
A
GLU
0.51
0.33
0.68
10
31
A
GLY
0.85
0.41
0.60
10
33
A
THR
0.43
0.33
0.72
10
34
A
SER
0.67
0.36
0.66
10
35
A
GLY
1.00
0.41
0.53
10
36
A
HIS
0.88
0.60
0.60
10
37
A
CYS
0.95
0.64
0.51
10
38
A
GLY
0.55
0.41
0.53
10
39
A
PHE
0.60
1.00
0.68
10
40
A
LYS
0.29
0.25
0.54
9
41
A
VAL
0.45
0.56
0.75
10
42
A
GLY
0.34
0.41
0.73
6
43
A
HIS
0.66
0.60
0.59
10
44
A
GLY
0.79
0.41
0.61
10
45
A
LEU
0.68
0.70
0.60
10
48
A
TRP
0.80
0.99
0.42
10
50
A
ASN
0.60
0.39
0.60
10
51
A
ALA
0.62
0.38
0.66
10
53
A
PRO
0.98
0.47
0.69
10
54
A
ASP
0.73
0.32
0.77
10
55
A
ASN
0.40
0.39
0.74
10
56
A
VAL
0.76
0.56
0.51
10
57
A
GLY
0.64
0.41
0.44
5
58
A
ILE
0.66
0.64
0.28
8
59
A
ILE
0.66
0.64
0.29
8
60
A
VAL
0.50
0.56
0.55
10
61
A
GLU
0.52
0.33
0.70
8
62
A
GLY
0.75
0.41
0.79
8
63
A
GLU
0.70
0.33
0.78
8
64
A
LYS
0.71
0.25
0.80
8
65
A
CYS
0.83
0.64
0.67
8
66
A
HIS
0.57
0.60
0.76
8
67
A
SER
0.16
0.36
0.76
8
1
A
VAL
0.32
0.56
0.77
10
2
A
ARG
0.58
0.51
0.59
10
3
A
ASP
0.85
0.32
0.59
10
4
A
GLY
0.87
0.41
0.39
10
5
A
TYR
1.00
0.80
0.36
10
8
A
GLN
0.45
0.43
0.44
4
9
A
PRO
0.49
0.47
0.50
9
13
A
VAL
0.84
0.56
0.36
10
14
A
TYR
0.69
0.80
0.33
10
15
A
HIS
0.57
0.60
0.56
10
16
A
CYS
1.00
0.64
0.53
10
17
A
PHE
0.29
1.00
0.72
10
18
A
PRO
0.49
0.47
0.77
10
19
A
GLY
0.36
0.41
0.73
10
20
A
SER
0.56
0.36
0.70
10
21
A
SER
0.25
0.36
0.77
10
22
A
GLY
0.59
0.41
0.62
10
24
A
ASP
0.69
0.32
0.62
10
25
A
THR
0.41
0.33
0.70
10
26
A
LEU
0.81
0.70
0.51
10
28
A
LYS
0.67
0.25
0.72
10
29
A
GLU
0.51
0.33
0.70
10
30
A
LYS
0.44
0.25
0.55
6
31
A
GLY
0.85
0.41
0.64
10
33
A
THR
0.43
0.33
0.74
10
34
A
SER
0.67
0.36
0.65
10
35
A
GLY
1.00
0.41
0.50
10
36
A
HIS
0.88
0.60
0.56
10
37
A
CYS
0.95
0.64
0.51
10
38
A
GLY
0.55
0.41
0.54
10
39
A
PHE
0.60
1.00
0.70
10
40
A
LYS
0.29
0.25
0.55
8
41
A
VAL
0.45
0.56
0.77
4
42
A
GLY
0.34
0.41
0.74
3
43
A
HIS
0.66
0.60
0.62
5
44
A
GLY
0.79
0.41
0.62
5
45
A
LEU
0.68
0.70
0.60
10
48
A
TRP
0.80
0.99
0.43
10
50
A
ASN
0.60
0.39
0.60
10
51
A
ALA
0.62
0.38
0.66
10
53
A
PRO
0.98
0.47
0.69
10
54
A
ASP
0.73
0.32
0.77
10
55
A
ASN
0.40
0.39
0.74
10
56
A
VAL
0.76
0.56
0.51
10
58
A
ILE
0.66
0.64
0.31
10
59
A
ILE
0.66
0.64
0.31
10
60
A
VAL
0.50
0.56
0.61
3
61
A
GLU
0.52
0.33
0.72
1
62
A
GLY
0.75
0.41
0.64
2
63
A
GLU
0.70
0.33
0.77
1
64
A
LYS
0.71
0.25
0.78
1
65
A
CYS
0.83
0.64
0.68
2
66
A
HIS
0.57
0.60
0.74
1
67
A
SER
0.16
0.36
0.76
1
1
A
VAL
0.32
0.56
0.77
10
2
A
ARG
0.58
0.51
0.62
10
3
A
ASP
0.85
0.32
0.63
10
4
A
GLY
0.87
0.41
0.41
10
5
A
TYR
1.00
0.80
0.36
10
8
A
GLN
0.45
0.43
0.43
2
9
A
PRO
0.49
0.47
0.52
9
10
A
GLU
0.35
0.33
0.67
5
12
A
CYS
1.00
0.64
0.42
5
13
A
VAL
0.84
0.56
0.34
9
14
A
TYR
0.69
0.80
0.30
10
15
A
HIS
0.57
0.60
0.52
10
16
A
CYS
1.00
0.64
0.47
10
17
A
PHE
0.29
1.00
0.68
10
18
A
PRO
0.49
0.47
0.77
10
19
A
GLY
0.36
0.41
0.80
6
20
A
SER
0.56
0.36
0.70
10
21
A
SER
0.25
0.36
0.78
9
22
A
GLY
0.59
0.41
0.67
9
24
A
ASP
0.69
0.32
0.63
4
25
A
THR
0.41
0.33
0.71
9
26
A
LEU
0.81
0.70
0.50
10
28
A
LYS
0.67
0.25
0.72
6
29
A
GLU
0.51
0.33
0.68
10
31
A
GLY
0.85
0.41
0.60
10
33
A
THR
0.43
0.33
0.72
8
34
A
SER
0.67
0.36
0.64
10
35
A
GLY
1.00
0.41
0.52
10
36
A
HIS
0.88
0.60
0.62
10
37
A
CYS
0.95
0.64
0.56
10
38
A
GLY
0.55
0.41
0.54
10
39
A
PHE
0.60
1.00
0.68
10
40
A
LYS
0.29
0.25
0.58
7
41
A
VAL
0.45
0.56
0.76
6
42
A
GLY
0.34
0.41
0.73
6
43
A
HIS
0.66
0.60
0.58
6
44
A
GLY
0.79
0.41
0.59
6
45
A
LEU
0.68
0.70
0.58
10
48
A
TRP
0.80
0.99
0.46
10
50
A
ASN
0.60
0.39
0.62
10
51
A
ALA
0.62
0.38
0.65
10
53
A
PRO
0.98
0.47
0.69
10
54
A
ASP
0.73
0.32
0.76
10
55
A
ASN
0.40
0.39
0.73
10
56
A
VAL
0.76
0.56
0.50
10
57
A
GLY
0.64
0.41
0.47
6
58
A
ILE
0.66
0.64
0.33
10
59
A
ILE
0.66
0.64
0.32
7
60
A
VAL
0.50
0.56
0.62
5
61
A
GLU
0.52
0.33
0.71
5
62
A
GLY
0.75
0.41
0.82
5
63
A
GLU
0.70
0.33
0.81
5
64
A
LYS
0.71
0.25
0.74
5
65
A
CYS
0.83
0.64
0.66
5
66
A
HIS
0.57
0.60
0.75
5
67
A
SER
0.16
0.36
0.66
5
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.60
10
3
A
ASP
0.85
0.32
0.61
10
4
A
GLY
0.87
0.41
0.39
10
5
A
TYR
1.00
0.80
0.36
10
8
A
GLN
0.45
0.43
0.43
3
9
A
PRO
0.49
0.47
0.51
6
10
A
GLU
0.35
0.33
0.62
1
13
A
VAL
0.84
0.56
0.34
8
14
A
TYR
0.69
0.80
0.31
10
15
A
HIS
0.57
0.60
0.53
10
17
A
PHE
0.29
1.00
0.69
10
18
A
PRO
0.49
0.47
0.79
10
19
A
GLY
0.36
0.41
0.79
10
20
A
SER
0.56
0.36
0.66
10
21
A
SER
0.25
0.36
0.78
9
22
A
GLY
0.59
0.41
0.69
9
24
A
ASP
0.69
0.32
0.66
8
25
A
THR
0.41
0.33
0.72
8
26
A
LEU
0.81
0.70
0.51
10
28
A
LYS
0.67
0.25
0.70
10
29
A
GLU
0.51
0.33
0.68
10
31
A
GLY
0.85
0.41
0.62
10
33
A
THR
0.43
0.33
0.73
8
34
A
SER
0.67
0.36
0.67
10
35
A
GLY
1.00
0.41
0.55
10
36
A
HIS
0.88
0.60
0.62
10
37
A
CYS
0.95
0.64
0.57
10
38
A
GLY
0.55
0.41
0.56
10
39
A
PHE
0.60
1.00
0.67
10
40
A
LYS
0.29
0.25
0.53
3
41
A
VAL
0.45
0.56
0.74
10
42
A
GLY
0.34
0.41
0.71
7
43
A
HIS
0.66
0.60
0.55
9
44
A
GLY
0.79
0.41
0.59
9
45
A
LEU
0.68
0.70
0.60
10
48
A
TRP
0.80
0.99
0.44
10
50
A
ASN
0.60
0.39
0.61
10
51
A
ALA
0.62
0.38
0.67
10
53
A
PRO
0.98
0.47
0.68
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.73
10
56
A
VAL
0.76
0.56
0.50
10
57
A
GLY
0.64
0.41
0.45
4
58
A
ILE
0.66
0.64
0.30
7
59
A
ILE
0.66
0.64
0.33
8
60
A
VAL
0.50
0.56
0.61
1
61
A
GLU
0.52
0.33
0.71
1
62
A
GLY
0.75
0.41
0.70
1
63
A
GLU
0.70
0.33
0.80
1
64
A
LYS
0.71
0.25
0.81
1
65
A
CYS
0.83
0.64
0.68
7
66
A
HIS
0.57
0.60
0.76
1
67
A
SER
0.16
0.36
0.77
1
1
A
VAL
0.32
0.56
0.78
10
2
A
ARG
0.58
0.51
0.60
10
3
A
ASP
0.85
0.32
0.60
10
4
A
GLY
0.87
0.41
0.38
10
5
A
TYR
1.00
0.80
0.35
10
9
A
PRO
0.49
0.47
0.53
8
14
A
TYR
0.69
0.80
0.29
8
15
A
HIS
0.57
0.60
0.48
8
17
A
PHE
0.29
1.00
0.70
10
18
A
PRO
0.49
0.47
0.78
10
19
A
GLY
0.36
0.41
0.76
10
20
A
SER
0.56
0.36
0.76
10
21
A
SER
0.25
0.36
0.77
9
22
A
GLY
0.59
0.41
0.61
7
24
A
ASP
0.69
0.32
0.64
5
25
A
THR
0.41
0.33
0.68
6
26
A
LEU
0.81
0.70
0.47
10
28
A
LYS
0.67
0.25
0.72
8
29
A
GLU
0.51
0.33
0.67
6
30
A
LYS
0.44
0.25
0.53
3
31
A
GLY
0.85
0.41
0.61
10
33
A
THR
0.43
0.33
0.73
9
34
A
SER
0.67
0.36
0.67
10
35
A
GLY
1.00
0.41
0.55
10
36
A
HIS
0.88
0.60
0.59
10
37
A
CYS
0.95
0.64
0.56
10
38
A
GLY
0.55
0.41
0.52
10
39
A
PHE
0.60
1.00
0.65
10
40
A
LYS
0.29
0.25
0.55
5
41
A
VAL
0.45
0.56
0.76
5
42
A
GLY
0.34
0.41
0.72
5
43
A
HIS
0.66
0.60
0.54
6
44
A
GLY
0.79
0.41
0.57
6
45
A
LEU
0.68
0.70
0.58
10
48
A
TRP
0.80
0.99
0.44
10
50
A
ASN
0.60
0.39
0.62
10
51
A
ALA
0.62
0.38
0.68
10
53
A
PRO
0.98
0.47
0.68
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.72
10
56
A
VAL
0.76
0.56
0.48
10
58
A
ILE
0.66
0.64
0.34
8
59
A
ILE
0.66
0.64
0.30
6
1
A
VAL
0.32
0.56
0.77
10
2
A
ARG
0.58
0.51
0.58
10
3
A
ASP
0.85
0.32
0.61
10
4
A
GLY
0.87
0.41
0.37
10
5
A
TYR
1.00
0.80
0.31
10
8
A
GLN
0.45
0.43
0.45
5
9
A
PRO
0.49
0.47
0.53
9
10
A
GLU
0.35
0.33
0.65
4
12
A
CYS
1.00
0.64
0.49
6
13
A
VAL
0.84
0.56
0.35
10
14
A
TYR
0.69
0.80
0.33
10
15
A
HIS
0.57
0.60
0.55
10
16
A
CYS
1.00
0.64
0.48
10
17
A
PHE
0.29
1.00
0.70
10
18
A
PRO
0.49
0.47
0.78
10
19
A
GLY
0.36
0.41
0.79
10
20
A
SER
0.56
0.36
0.66
10
21
A
SER
0.25
0.36
0.78
9
22
A
GLY
0.59
0.41
0.69
9
24
A
ASP
0.69
0.32
0.59
8
25
A
THR
0.41
0.33
0.69
9
26
A
LEU
0.81
0.70
0.52
10
28
A
LYS
0.67
0.25
0.65
8
29
A
GLU
0.51
0.33
0.68
10
31
A
GLY
0.85
0.41
0.62
10
32
A
GLY
0.76
0.41
0.52
2
33
A
THR
0.43
0.33
0.72
10
34
A
SER
0.67
0.36
0.67
10
35
A
GLY
1.00
0.41
0.55
10
36
A
HIS
0.88
0.60
0.60
10
37
A
CYS
0.95
0.64
0.55
10
38
A
GLY
0.55
0.41
0.56
10
39
A
PHE
0.60
1.00
0.63
10
40
A
LYS
0.29
0.25
0.73
10
41
A
VAL
0.45
0.56
0.51
10
42
A
GLY
0.34
0.41
0.67
4
43
A
HIS
0.66
0.60
0.55
4
44
A
GLY
0.79
0.41
0.63
6
45
A
LEU
0.68
0.70
0.58
10
48
A
TRP
0.80
0.99
0.44
10
50
A
ASN
0.60
0.39
0.61
10
51
A
ALA
0.62
0.38
0.65
10
53
A
PRO
0.98
0.47
0.68
10
54
A
ASP
0.73
0.32
0.76
10
55
A
ASN
0.40
0.39
0.75
10
56
A
VAL
0.76
0.56
0.52
10
57
A
GLY
0.64
0.41
0.45
8
58
A
ILE
0.66
0.64
0.28
9
59
A
ILE
0.66
0.64
0.29
9
60
A
VAL
0.50
0.56
0.59
4
61
A
GLU
0.52
0.33
0.70
4
62
A
GLY
0.75
0.41
0.69
4
63
A
GLU
0.70
0.33
0.78
4
64
A
LYS
0.71
0.25
0.79
4
65
A
CYS
0.83
0.64
0.69
4
66
A
HIS
0.57
0.60
0.75
4
67
A
SER
0.16
0.36
0.82
4
1
A
VAL
0.32
0.56
0.77
10
2
A
ARG
0.58
0.51
0.58
10
3
A
ASP
0.85
0.32
0.60
10
4
A
GLY
0.87
0.41
0.37
10
5
A
TYR
1.00
0.80
0.36
10
8
A
GLN
0.45
0.43
0.42
7
9
A
PRO
0.49
0.47
0.51
10
10
A
GLU
0.35
0.33
0.63
1
14
A
TYR
0.69
0.80
0.29
10
15
A
HIS
0.57
0.60
0.55
10
16
A
CYS
1.00
0.64
0.48
10
17
A
PHE
0.29
1.00
0.68
10
18
A
PRO
0.49
0.47
0.79
10
19
A
GLY
0.36
0.41
0.73
10
20
A
SER
0.56
0.36
0.67
10
21
A
SER
0.25
0.36
0.76
10
22
A
GLY
0.59
0.41
0.64
10
24
A
ASP
0.69
0.32
0.64
10
25
A
THR
0.41
0.33
0.70
10
26
A
LEU
0.81
0.70
0.48
10
28
A
LYS
0.67
0.25
0.73
10
29
A
GLU
0.51
0.33
0.68
10
31
A
GLY
0.85
0.41
0.63
10
32
A
GLY
0.76
0.41
0.55
7
33
A
THR
0.43
0.33
0.72
10
34
A
SER
0.67
0.36
0.66
10
36
A
HIS
0.88
0.60
0.62
10
37
A
CYS
0.95
0.64
0.53
10
38
A
GLY
0.55
0.41
0.52
10
39
A
PHE
0.60
1.00
0.62
10
40
A
LYS
0.29
0.25
0.58
9
41
A
VAL
0.45
0.56
0.77
4
42
A
GLY
0.34
0.41
0.67
5
43
A
HIS
0.66
0.60
0.59
5
44
A
GLY
0.79
0.41
0.64
5
45
A
LEU
0.68
0.70
0.57
10
48
A
TRP
0.80
0.99
0.43
10
50
A
ASN
0.60
0.39
0.61
10
51
A
ALA
0.62
0.38
0.67
10
53
A
PRO
0.98
0.47
0.68
10
54
A
ASP
0.73
0.32
0.74
10
55
A
ASN
0.40
0.39
0.74
10
56
A
VAL
0.76
0.56
0.48
10
57
A
GLY
0.64
0.41
0.42
6
58
A
ILE
0.66
0.64
0.33
10
59
A
ILE
0.66
0.64
0.30
9
60
A
VAL
0.50
0.56
0.61
3
61
A
GLU
0.52
0.33
0.72
3
62
A
GLY
0.75
0.41
0.67
3
63
A
GLU
0.70
0.33
0.78
3
64
A
LYS
0.71
0.25
0.79
3
65
A
CYS
0.83
0.64
0.66
3
66
A
HIS
0.57
0.60
0.73
3
67
A
SER
0.16
0.36
0.77
3
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.57
10
3
A
ASP
0.85
0.32
0.61
10
4
A
GLY
0.87
0.41
0.39
10
5
A
TYR
1.00
0.80
0.34
10
8
A
GLN
0.45
0.43
0.44
6
9
A
PRO
0.49
0.47
0.53
9
10
A
GLU
0.35
0.33
0.65
2
12
A
CYS
1.00
0.64
0.48
6
13
A
VAL
0.84
0.56
0.35
10
14
A
TYR
0.69
0.80
0.33
8
15
A
HIS
0.57
0.60
0.51
8
17
A
PHE
0.29
1.00
0.71
10
18
A
PRO
0.49
0.47
0.78
10
19
A
GLY
0.36
0.41
0.76
10
20
A
SER
0.56
0.36
0.75
10
21
A
SER
0.25
0.36
0.78
10
24
A
ASP
0.69
0.32
0.64
10
25
A
THR
0.41
0.33
0.69
10
26
A
LEU
0.81
0.70
0.49
9
28
A
LYS
0.67
0.25
0.71
9
29
A
GLU
0.51
0.33
0.67
9
31
A
GLY
0.85
0.41
0.62
9
32
A
GLY
0.76
0.41
0.52
6
33
A
THR
0.43
0.33
0.72
10
34
A
SER
0.67
0.36
0.66
10
35
A
GLY
1.00
0.41
0.54
10
36
A
HIS
0.88
0.60
0.59
10
37
A
CYS
0.95
0.64
0.57
10
38
A
GLY
0.55
0.41
0.53
10
39
A
PHE
0.60
1.00
0.66
10
40
A
LYS
0.29
0.25
0.51
8
41
A
VAL
0.45
0.56
0.74
10
42
A
GLY
0.34
0.41
0.73
8
43
A
HIS
0.66
0.60
0.56
8
44
A
GLY
0.79
0.41
0.60
8
45
A
LEU
0.68
0.70
0.60
10
48
A
TRP
0.80
0.99
0.43
10
50
A
ASN
0.60
0.39
0.61
10
51
A
ALA
0.62
0.38
0.66
10
53
A
PRO
0.98
0.47
0.68
9
54
A
ASP
0.73
0.32
0.74
9
55
A
ASN
0.40
0.39
0.74
9
56
A
VAL
0.76
0.56
0.50
9
57
A
GLY
0.64
0.41
0.48
9
59
A
ILE
0.66
0.64
0.33
10
60
A
VAL
0.50
0.56
0.59
4
61
A
GLU
0.52
0.33
0.77
2
62
A
GLY
0.75
0.41
0.67
2
63
A
GLU
0.70
0.33
0.80
2
64
A
LYS
0.71
0.25
0.75
2
65
A
CYS
0.83
0.64
0.68
6
66
A
HIS
0.57
0.60
0.75
2
67
A
SER
0.16
0.36
0.83
2
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.61
10
3
A
ASP
0.85
0.32
0.59
10
4
A
GLY
0.87
0.41
0.36
10
5
A
TYR
1.00
0.80
0.32
10
8
A
GLN
0.45
0.43
0.47
3
9
A
PRO
0.49
0.47
0.56
10
10
A
GLU
0.35
0.33
0.64
3
12
A
CYS
1.00
0.64
0.41
3
13
A
VAL
0.84
0.56
0.34
8
14
A
TYR
0.69
0.80
0.32
10
15
A
HIS
0.57
0.60
0.55
10
17
A
PHE
0.29
1.00
0.67
10
18
A
PRO
0.49
0.47
0.78
10
19
A
GLY
0.36
0.41
0.78
10
20
A
SER
0.56
0.36
0.71
10
21
A
SER
0.25
0.36
0.76
10
22
A
GLY
0.59
0.41
0.68
10
24
A
ASP
0.69
0.32
0.59
10
25
A
THR
0.41
0.33
0.70
10
26
A
LEU
0.81
0.70
0.52
10
28
A
LYS
0.67
0.25
0.71
10
29
A
GLU
0.51
0.33
0.69
10
30
A
LYS
0.44
0.25
0.53
4
31
A
GLY
0.85
0.41
0.60
10
33
A
THR
0.43
0.33
0.72
10
34
A
SER
0.67
0.36
0.65
10
35
A
GLY
1.00
0.41
0.53
10
36
A
HIS
0.88
0.60
0.58
10
37
A
CYS
0.95
0.64
0.54
10
38
A
GLY
0.55
0.41
0.50
10
39
A
PHE
0.60
1.00
0.65
10
41
A
VAL
0.45
0.56
0.74
10
42
A
GLY
0.34
0.41
0.72
9
43
A
HIS
0.66
0.60
0.57
9
44
A
GLY
0.79
0.41
0.58
9
45
A
LEU
0.68
0.70
0.58
10
48
A
TRP
0.80
0.99
0.42
10
50
A
ASN
0.60
0.39
0.61
10
51
A
ALA
0.62
0.38
0.66
10
53
A
PRO
0.98
0.47
0.67
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.73
10
56
A
VAL
0.76
0.56
0.49
10
57
A
GLY
0.64
0.41
0.46
6
58
A
ILE
0.66
0.64
0.30
10
59
A
ILE
0.66
0.64
0.29
8
60
A
VAL
0.50
0.56
0.59
3
61
A
GLU
0.52
0.33
0.70
3
62
A
GLY
0.75
0.41
0.68
3
63
A
GLU
0.70
0.33
0.79
3
64
A
LYS
0.71
0.25
0.79
3
65
A
CYS
0.83
0.64
0.67
3
66
A
HIS
0.57
0.60
0.77
3
67
A
SER
0.16
0.36
0.76
3
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.59
10
3
A
ASP
0.85
0.32
0.59
10
4
A
GLY
0.87
0.41
0.35
10
5
A
TYR
1.00
0.80
0.30
10
8
A
GLN
0.45
0.43
0.45
3
9
A
PRO
0.49
0.47
0.56
10
10
A
GLU
0.35
0.33
0.64
8
12
A
CYS
1.00
0.64
0.40
8
14
A
TYR
0.69
0.80
0.31
10
15
A
HIS
0.57
0.60
0.55
10
16
A
CYS
1.00
0.64
0.46
10
17
A
PHE
0.29
1.00
0.68
10
18
A
PRO
0.49
0.47
0.74
10
19
A
GLY
0.36
0.41
0.78
10
20
A
SER
0.56
0.36
0.65
10
21
A
SER
0.25
0.36
0.76
10
22
A
GLY
0.59
0.41
0.64
10
24
A
ASP
0.69
0.32
0.60
10
25
A
THR
0.41
0.33
0.69
9
26
A
LEU
0.81
0.70
0.50
10
28
A
LYS
0.67
0.25
0.71
10
29
A
GLU
0.51
0.33
0.69
10
31
A
GLY
0.85
0.41
0.63
10
33
A
THR
0.43
0.33
0.72
10
34
A
SER
0.67
0.36
0.66
10
36
A
HIS
0.88
0.60
0.61
10
37
A
CYS
0.95
0.64
0.53
10
38
A
GLY
0.55
0.41
0.52
10
39
A
PHE
0.60
1.00
0.66
10
40
A
LYS
0.29
0.25
0.70
10
41
A
VAL
0.45
0.56
0.71
9
42
A
GLY
0.34
0.41
0.54
9
43
A
HIS
0.66
0.60
0.55
9
44
A
GLY
0.79
0.41
0.57
9
45
A
LEU
0.68
0.70
0.58
10
48
A
TRP
0.80
0.99
0.42
10
50
A
ASN
0.60
0.39
0.62
10
53
A
PRO
0.98
0.47
0.68
10
54
A
ASP
0.73
0.32
0.74
10
55
A
ASN
0.40
0.39
0.74
10
56
A
VAL
0.76
0.56
0.51
10
57
A
GLY
0.64
0.41
0.48
6
58
A
ILE
0.66
0.64
0.30
8
59
A
ILE
0.66
0.64
0.31
9
60
A
VAL
0.50
0.56
0.60
10
61
A
GLU
0.52
0.33
0.71
7
62
A
GLY
0.75
0.41
0.69
7
63
A
GLU
0.70
0.33
0.78
7
64
A
LYS
0.71
0.25
0.80
7
65
A
CYS
0.83
0.64
0.66
8
66
A
HIS
0.57
0.60
0.77
7
67
A
SER
0.16
0.36
0.76
8
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.59
10
3
A
ASP
0.85
0.32
0.60
10
4
A
GLY
0.87
0.41
0.36
10
5
A
TYR
1.00
0.80
0.35
10
8
A
GLN
0.45
0.43
0.45
4
9
A
PRO
0.49
0.47
0.53
8
10
A
GLU
0.35
0.33
0.66
5
12
A
CYS
1.00
0.64
0.49
6
13
A
VAL
0.84
0.56
0.38
10
14
A
TYR
0.69
0.80
0.33
10
15
A
HIS
0.57
0.60
0.57
6
17
A
PHE
0.29
1.00
0.70
10
18
A
PRO
0.49
0.47
0.79
10
19
A
GLY
0.36
0.41
0.79
6
20
A
SER
0.56
0.36
0.64
10
21
A
SER
0.25
0.36
0.77
10
22
A
GLY
0.59
0.41
0.69
10
24
A
ASP
0.69
0.32
0.60
10
25
A
THR
0.41
0.33
0.71
10
26
A
LEU
0.81
0.70
0.54
10
28
A
LYS
0.67
0.25
0.70
10
29
A
GLU
0.51
0.33
0.70
10
31
A
GLY
0.85
0.41
0.62
10
33
A
THR
0.43
0.33
0.74
10
34
A
SER
0.67
0.36
0.67
10
35
A
GLY
1.00
0.41
0.54
10
36
A
HIS
0.88
0.60
0.61
10
37
A
CYS
0.95
0.64
0.55
10
38
A
GLY
0.55
0.41
0.55
10
39
A
PHE
0.60
1.00
0.68
10
40
A
LYS
0.29
0.25
0.54
8
41
A
VAL
0.45
0.56
0.77
6
42
A
GLY
0.34
0.41
0.74
6
43
A
HIS
0.66
0.60
0.60
6
44
A
GLY
0.79
0.41
0.62
6
45
A
LEU
0.68
0.70
0.62
10
48
A
TRP
0.80
0.99
0.43
10
50
A
ASN
0.60
0.39
0.60
10
51
A
ALA
0.62
0.38
0.66
10
53
A
PRO
0.98
0.47
0.68
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.73
10
56
A
VAL
0.76
0.56
0.49
10
57
A
GLY
0.64
0.41
0.44
7
58
A
ILE
0.66
0.64
0.27
8
59
A
ILE
0.66
0.64
0.32
9
60
A
VAL
0.50
0.56
0.57
7
61
A
GLU
0.52
0.33
0.76
5
62
A
GLY
0.75
0.41
0.73
5
63
A
GLU
0.70
0.33
0.65
5
64
A
LYS
0.71
0.25
0.77
6
65
A
CYS
0.83
0.64
0.70
6
66
A
HIS
0.57
0.60
0.75
5
67
A
SER
0.16
0.36
0.77
5
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.57
10
3
A
ASP
0.85
0.32
0.60
10
4
A
GLY
0.87
0.41
0.38
10
5
A
TYR
1.00
0.80
0.34
10
8
A
GLN
0.45
0.43
0.44
5
9
A
PRO
0.49
0.47
0.52
6
10
A
GLU
0.35
0.33
0.66
5
12
A
CYS
1.00
0.64
0.44
5
13
A
VAL
0.84
0.56
0.35
10
14
A
TYR
0.69
0.80
0.33
10
15
A
HIS
0.57
0.60
0.61
10
16
A
CYS
1.00
0.64
0.47
10
17
A
PHE
0.29
1.00
0.67
10
18
A
PRO
0.49
0.47
0.78
10
19
A
GLY
0.36
0.41
0.71
10
20
A
SER
0.56
0.36
0.65
10
21
A
SER
0.25
0.36
0.77
10
22
A
GLY
0.59
0.41
0.68
10
24
A
ASP
0.69
0.32
0.67
10
25
A
THR
0.41
0.33
0.72
10
26
A
LEU
0.81
0.70
0.52
10
28
A
LYS
0.67
0.25
0.72
10
29
A
GLU
0.51
0.33
0.69
10
31
A
GLY
0.85
0.41
0.64
10
33
A
THR
0.43
0.33
0.74
10
34
A
SER
0.67
0.36
0.65
10
35
A
GLY
1.00
0.41
0.51
10
36
A
HIS
0.88
0.60
0.58
10
37
A
CYS
0.95
0.64
0.47
10
38
A
GLY
0.55
0.41
0.53
10
39
A
PHE
0.60
1.00
0.66
10
40
A
LYS
0.29
0.25
0.73
10
41
A
VAL
0.45
0.56
0.73
4
42
A
GLY
0.34
0.41
0.57
5
43
A
HIS
0.66
0.60
0.57
5
44
A
GLY
0.79
0.41
0.58
5
45
A
LEU
0.68
0.70
0.58
10
48
A
TRP
0.80
0.99
0.42
10
50
A
ASN
0.60
0.39
0.61
10
51
A
ALA
0.62
0.38
0.67
10
53
A
PRO
0.98
0.47
0.67
10
54
A
ASP
0.73
0.32
0.73
10
55
A
ASN
0.40
0.39
0.71
10
57
A
GLY
0.64
0.41
0.44
8
58
A
ILE
0.66
0.64
0.31
9
59
A
ILE
0.66
0.64
0.30
9
60
A
VAL
0.50
0.56
0.59
6
61
A
GLU
0.52
0.33
0.66
5
62
A
GLY
0.75
0.41
0.79
5
63
A
GLU
0.70
0.33
0.81
5
64
A
LYS
0.71
0.25
0.74
5
65
A
CYS
0.83
0.64
0.68
5
66
A
HIS
0.57
0.60
0.77
5
67
A
SER
0.16
0.36
0.81
5
1
A
VAL
0.32
0.56
0.75
10
2
A
ARG
0.58
0.51
0.57
10
3
A
ASP
0.85
0.32
0.62
10
4
A
GLY
0.87
0.41
0.39
10
5
A
TYR
1.00
0.80
0.36
10
8
A
GLN
0.45
0.43
0.45
5
9
A
PRO
0.49
0.47
0.55
10
10
A
GLU
0.35
0.33
0.66
9
12
A
CYS
1.00
0.64
0.50
9
13
A
VAL
0.84
0.56
0.39
10
14
A
TYR
0.69
0.80
0.37
10
15
A
HIS
0.57
0.60
0.54
10
17
A
PHE
0.29
1.00
0.69
10
18
A
PRO
0.49
0.47
0.77
10
19
A
GLY
0.36
0.41
0.74
10
20
A
SER
0.56
0.36
0.71
10
21
A
SER
0.25
0.36
0.78
10
22
A
GLY
0.59
0.41
0.68
10
24
A
ASP
0.69
0.32
0.61
7
25
A
THR
0.41
0.33
0.72
10
26
A
LEU
0.81
0.70
0.56
10
28
A
LYS
0.67
0.25
0.73
10
29
A
GLU
0.51
0.33
0.70
10
31
A
GLY
0.85
0.41
0.60
10
33
A
THR
0.43
0.33
0.72
9
34
A
SER
0.67
0.36
0.62
10
36
A
HIS
0.88
0.60
0.60
10
37
A
CYS
0.95
0.64
0.54
10
38
A
GLY
0.55
0.41
0.55
10
39
A
PHE
0.60
1.00
0.68
10
40
A
LYS
0.29
0.25
0.54
6
41
A
VAL
0.45
0.56
0.75
10
42
A
GLY
0.34
0.41
0.73
10
43
A
HIS
0.66
0.60
0.56
10
44
A
GLY
0.79
0.41
0.63
10
45
A
LEU
0.68
0.70
0.61
10
48
A
TRP
0.80
0.99
0.45
10
50
A
ASN
0.60
0.39
0.61
10
51
A
ALA
0.62
0.38
0.65
10
53
A
PRO
0.98
0.47
0.67
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.73
10
56
A
VAL
0.76
0.56
0.50
10
57
A
GLY
0.64
0.41
0.44
3
58
A
ILE
0.66
0.64
0.28
7
59
A
ILE
0.66
0.64
0.31
7
60
A
VAL
0.50
0.56
0.56
9
61
A
GLU
0.52
0.33
0.75
9
62
A
GLY
0.75
0.41
0.76
9
63
A
GLU
0.70
0.33
0.81
9
64
A
LYS
0.71
0.25
0.73
9
65
A
CYS
0.83
0.64
0.70
9
66
A
HIS
0.57
0.60
0.77
9
67
A
SER
0.16
0.36
0.83
5
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.59
10
3
A
ASP
0.85
0.32
0.61
10
4
A
GLY
0.87
0.41
0.38
10
5
A
TYR
1.00
0.80
0.37
10
8
A
GLN
0.45
0.43
0.43
3
9
A
PRO
0.49
0.47
0.51
10
10
A
GLU
0.35
0.33
0.65
2
13
A
VAL
0.84
0.56
0.33
9
14
A
TYR
0.69
0.80
0.31
10
15
A
HIS
0.57
0.60
0.55
10
16
A
CYS
1.00
0.64
0.52
10
17
A
PHE
0.29
1.00
0.69
10
18
A
PRO
0.49
0.47
0.77
10
19
A
GLY
0.36
0.41
0.79
10
20
A
SER
0.56
0.36
0.66
10
21
A
SER
0.25
0.36
0.76
10
22
A
GLY
0.59
0.41
0.64
10
24
A
ASP
0.69
0.32
0.60
9
25
A
THR
0.41
0.33
0.69
10
26
A
LEU
0.81
0.70
0.50
10
28
A
LYS
0.67
0.25
0.73
10
29
A
GLU
0.51
0.33
0.69
10
31
A
GLY
0.85
0.41
0.63
10
32
A
GLY
0.76
0.41
0.56
10
33
A
THR
0.43
0.33
0.73
10
34
A
SER
0.67
0.36
0.67
10
35
A
GLY
1.00
0.41
0.52
10
36
A
HIS
0.88
0.60
0.57
10
37
A
CYS
0.95
0.64
0.52
10
38
A
GLY
0.55
0.41
0.47
10
39
A
PHE
0.60
1.00
0.66
10
40
A
LYS
0.29
0.25
0.54
5
41
A
VAL
0.45
0.56
0.76
7
42
A
GLY
0.34
0.41
0.76
5
43
A
HIS
0.66
0.60
0.58
8
44
A
GLY
0.79
0.41
0.61
8
45
A
LEU
0.68
0.70
0.60
10
48
A
TRP
0.80
0.99
0.44
10
50
A
ASN
0.60
0.39
0.61
10
51
A
ALA
0.62
0.38
0.67
10
53
A
PRO
0.98
0.47
0.69
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.72
10
56
A
VAL
0.76
0.56
0.49
10
57
A
GLY
0.64
0.41
0.43
4
58
A
ILE
0.66
0.64
0.27
6
59
A
ILE
0.66
0.64
0.29
10
60
A
VAL
0.50
0.56
0.55
8
61
A
GLU
0.52
0.33
0.74
1
62
A
GLY
0.75
0.41
0.70
1
63
A
GLU
0.70
0.33
0.77
2
64
A
LYS
0.71
0.25
0.77
2
65
A
CYS
0.83
0.64
0.66
3
66
A
HIS
0.57
0.60
0.76
2
67
A
SER
0.16
0.36
0.83
2
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.60
10
3
A
ASP
0.85
0.32
0.61
10
4
A
GLY
0.87
0.41
0.39
10
5
A
TYR
1.00
0.80
0.34
10
8
A
GLN
0.45
0.43
0.43
2
9
A
PRO
0.49
0.47
0.53
1
10
A
GLU
0.35
0.33
0.64
2
13
A
VAL
0.84
0.56
0.34
9
14
A
TYR
0.69
0.80
0.30
10
15
A
HIS
0.57
0.60
0.51
10
17
A
PHE
0.29
1.00
0.72
10
18
A
PRO
0.49
0.47
0.76
10
19
A
GLY
0.36
0.41
0.79
10
20
A
SER
0.56
0.36
0.68
10
21
A
SER
0.25
0.36
0.76
10
22
A
GLY
0.59
0.41
0.62
10
24
A
ASP
0.69
0.32
0.65
10
25
A
THR
0.41
0.33
0.69
9
26
A
LEU
0.81
0.70
0.46
10
28
A
LYS
0.67
0.25
0.73
10
29
A
GLU
0.51
0.33
0.67
10
31
A
GLY
0.85
0.41
0.61
10
32
A
GLY
0.76
0.41
0.54
6
33
A
THR
0.43
0.33
0.72
10
34
A
SER
0.67
0.36
0.67
10
35
A
GLY
1.00
0.41
0.54
10
36
A
HIS
0.88
0.60
0.60
10
37
A
CYS
0.95
0.64
0.55
10
38
A
GLY
0.55
0.41
0.54
10
39
A
PHE
0.60
1.00
0.67
10
40
A
LYS
0.29
0.25
0.54
6
41
A
VAL
0.45
0.56
0.75
10
42
A
GLY
0.34
0.41
0.72
7
43
A
HIS
0.66
0.60
0.56
9
44
A
GLY
0.79
0.41
0.59
9
45
A
LEU
0.68
0.70
0.60
10
48
A
TRP
0.80
0.99
0.44
10
50
A
ASN
0.60
0.39
0.62
10
51
A
ALA
0.62
0.38
0.66
10
53
A
PRO
0.98
0.47
0.68
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.72
10
57
A
GLY
0.64
0.41
0.44
4
58
A
ILE
0.66
0.64
0.28
8
59
A
ILE
0.66
0.64
0.31
10
60
A
VAL
0.50
0.56
0.58
2
61
A
GLU
0.52
0.33
0.76
2
62
A
GLY
0.75
0.41
0.72
2
63
A
GLU
0.70
0.33
0.73
2
64
A
LYS
0.71
0.25
0.78
2
65
A
CYS
0.83
0.64
0.71
2
66
A
HIS
0.57
0.60
0.77
2
67
A
SER
0.16
0.36
0.80
2
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.60
10
3
A
ASP
0.85
0.32
0.62
10
4
A
GLY
0.87
0.41
0.41
10
5
A
TYR
1.00
0.80
0.35
10
8
A
GLN
0.45
0.43
0.42
3
9
A
PRO
0.49
0.47
0.54
10
10
A
GLU
0.35
0.33
0.65
5
12
A
CYS
1.00
0.64
0.47
5
13
A
VAL
0.84
0.56
0.34
10
14
A
TYR
0.69
0.80
0.30
7
15
A
HIS
0.57
0.60
0.50
8
17
A
PHE
0.29
1.00
0.71
10
18
A
PRO
0.49
0.47
0.76
10
19
A
GLY
0.36
0.41
0.76
10
20
A
SER
0.56
0.36
0.75
10
21
A
SER
0.25
0.36
0.77
9
24
A
ASP
0.69
0.32
0.63
9
25
A
THR
0.41
0.33
0.68
10
26
A
LEU
0.81
0.70
0.46
10
28
A
LYS
0.67
0.25
0.72
9
29
A
GLU
0.51
0.33
0.66
10
31
A
GLY
0.85
0.41
0.59
10
33
A
THR
0.43
0.33
0.72
10
34
A
SER
0.67
0.36
0.66
10
35
A
GLY
1.00
0.41
0.54
10
36
A
HIS
0.88
0.60
0.63
10
37
A
CYS
0.95
0.64
0.57
10
38
A
GLY
0.55
0.41
0.54
10
39
A
PHE
0.60
1.00
0.67
10
40
A
LYS
0.29
0.25
0.52
6
41
A
VAL
0.45
0.56
0.74
10
42
A
GLY
0.34
0.41
0.71
6
43
A
HIS
0.66
0.60
0.54
6
44
A
GLY
0.79
0.41
0.59
6
45
A
LEU
0.68
0.70
0.59
10
48
A
TRP
0.80
0.99
0.45
10
50
A
ASN
0.60
0.39
0.62
10
51
A
ALA
0.62
0.38
0.67
10
53
A
PRO
0.98
0.47
0.68
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.74
10
56
A
VAL
0.76
0.56
0.50
10
57
A
GLY
0.64
0.41
0.44
6
58
A
ILE
0.66
0.64
0.30
10
59
A
ILE
0.66
0.64
0.32
10
60
A
VAL
0.50
0.56
0.60
5
61
A
GLU
0.52
0.33
0.72
5
62
A
GLY
0.75
0.41
0.82
5
63
A
GLU
0.70
0.33
0.78
5
64
A
LYS
0.71
0.25
0.80
5
65
A
CYS
0.83
0.64
0.69
5
66
A
HIS
0.57
0.60
0.76
5
67
A
SER
0.16
0.36
0.81
5
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.61
10
3
A
ASP
0.85
0.32
0.59
10
4
A
GLY
0.87
0.41
0.33
10
5
A
TYR
1.00
0.80
0.31
10
9
A
PRO
0.49
0.47
0.53
9
10
A
GLU
0.35
0.33
0.65
2
12
A
CYS
1.00
0.64
0.40
2
14
A
TYR
0.69
0.80
0.30
8
15
A
HIS
0.57
0.60
0.54
8
17
A
PHE
0.29
1.00
0.69
10
18
A
PRO
0.49
0.47
0.76
10
19
A
GLY
0.36
0.41
0.76
10
20
A
SER
0.56
0.36
0.65
10
21
A
SER
0.25
0.36
0.76
9
22
A
GLY
0.59
0.41
0.67
9
24
A
ASP
0.69
0.32
0.59
9
25
A
THR
0.41
0.33
0.69
8
26
A
LEU
0.81
0.70
0.49
10
28
A
LYS
0.67
0.25
0.71
10
29
A
GLU
0.51
0.33
0.68
10
30
A
LYS
0.44
0.25
0.54
1
31
A
GLY
0.85
0.41
0.64
10
33
A
THR
0.43
0.33
0.73
10
34
A
SER
0.67
0.36
0.68
10
35
A
GLY
1.00
0.41
0.55
10
36
A
HIS
0.88
0.60
0.59
10
37
A
CYS
0.95
0.64
0.51
10
38
A
GLY
0.55
0.41
0.53
10
39
A
PHE
0.60
1.00
0.65
10
40
A
LYS
0.29
0.25
0.72
10
41
A
VAL
0.45
0.56
0.52
10
42
A
GLY
0.34
0.41
0.68
5
43
A
HIS
0.66
0.60
0.58
5
44
A
GLY
0.79
0.41
0.58
5
45
A
LEU
0.68
0.70
0.55
10
48
A
TRP
0.80
0.99
0.44
10
50
A
ASN
0.60
0.39
0.64
10
51
A
ALA
0.62
0.38
0.60
8
53
A
PRO
0.98
0.47
0.67
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.72
10
56
A
VAL
0.76
0.56
0.48
10
57
A
GLY
0.64
0.41
0.42
6
58
A
ILE
0.66
0.64
0.31
9
59
A
ILE
0.66
0.64
0.31
10
60
A
VAL
0.50
0.56
0.60
2
61
A
GLU
0.52
0.33
0.68
2
62
A
GLY
0.75
0.41
0.80
2
63
A
GLU
0.70
0.33
0.81
2
64
A
LYS
0.71
0.25
0.78
2
65
A
CYS
0.83
0.64
0.67
2
66
A
HIS
0.57
0.60
0.77
2
67
A
SER
0.16
0.36
0.73
2
1
A
VAL
0.32
0.56
0.77
10
2
A
ARG
0.58
0.51
0.60
10
3
A
ASP
0.85
0.32
0.61
10
4
A
GLY
0.87
0.41
0.40
10
5
A
TYR
1.00
0.80
0.38
10
8
A
GLN
0.45
0.43
0.42
1
9
A
PRO
0.49
0.47
0.52
9
14
A
TYR
0.69
0.80
0.30
8
15
A
HIS
0.57
0.60
0.52
8
17
A
PHE
0.29
1.00
0.71
10
18
A
PRO
0.49
0.47
0.76
10
19
A
GLY
0.36
0.41
0.79
10
20
A
SER
0.56
0.36
0.67
10
21
A
SER
0.25
0.36
0.77
10
22
A
GLY
0.59
0.41
0.67
10
24
A
ASP
0.69
0.32
0.67
9
25
A
THR
0.41
0.33
0.71
10
26
A
LEU
0.81
0.70
0.51
10
28
A
LYS
0.67
0.25
0.71
10
29
A
GLU
0.51
0.33
0.68
10
31
A
GLY
0.85
0.41
0.62
10
33
A
THR
0.43
0.33
0.73
10
34
A
SER
0.67
0.36
0.65
10
35
A
GLY
1.00
0.41
0.51
10
36
A
HIS
0.88
0.60
0.58
10
37
A
CYS
0.95
0.64
0.55
10
38
A
GLY
0.55
0.41
0.51
10
39
A
PHE
0.60
1.00
0.62
10
40
A
LYS
0.29
0.25
0.75
10
41
A
VAL
0.45
0.56
0.54
10
42
A
GLY
0.34
0.41
0.70
4
43
A
HIS
0.66
0.60
0.63
5
44
A
GLY
0.79
0.41
0.68
5
45
A
LEU
0.68
0.70
0.57
10
48
A
TRP
0.80
0.99
0.45
10
50
A
ASN
0.60
0.39
0.62
10
51
A
ALA
0.62
0.38
0.67
10
53
A
PRO
0.98
0.47
0.69
10
54
A
ASP
0.73
0.32
0.77
10
55
A
ASN
0.40
0.39
0.73
10
56
A
VAL
0.76
0.56
0.50
10
57
A
GLY
0.64
0.41
0.46
8
58
A
ILE
0.66
0.64
0.35
10
59
A
ILE
0.66
0.64
0.33
10
60
A
VAL
0.50
0.56
0.63
2
61
A
GLU
0.52
0.33
0.73
2
62
A
GLY
0.75
0.41
0.68
2
63
A
GLU
0.70
0.33
0.80
2
64
A
LYS
0.71
0.25
0.79
2
65
A
CYS
0.83
0.64
0.66
2
66
A
HIS
0.57
0.60
0.74
1
67
A
SER
0.16
0.36
0.76
1
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.59
10
3
A
ASP
0.85
0.32
0.61
10
4
A
GLY
0.87
0.41
0.40
10
5
A
TYR
1.00
0.80
0.36
10
8
A
GLN
0.45
0.43
0.41
3
9
A
PRO
0.49
0.47
0.51
8
10
A
GLU
0.35
0.33
0.64
4
12
A
CYS
1.00
0.64
0.44
5
13
A
VAL
0.84
0.56
0.35
10
14
A
TYR
0.69
0.80
0.29
10
15
A
HIS
0.57
0.60
0.56
10
17
A
PHE
0.29
1.00
0.70
10
18
A
PRO
0.49
0.47
0.78
10
19
A
GLY
0.36
0.41
0.73
10
20
A
SER
0.56
0.36
0.65
10
21
A
SER
0.25
0.36
0.75
10
22
A
GLY
0.59
0.41
0.67
10
24
A
ASP
0.69
0.32
0.68
10
25
A
THR
0.41
0.33
0.72
10
26
A
LEU
0.81
0.70
0.52
10
28
A
LYS
0.67
0.25
0.72
10
29
A
GLU
0.51
0.33
0.68
10
31
A
GLY
0.85
0.41
0.63
10
33
A
THR
0.43
0.33
0.73
10
34
A
SER
0.67
0.36
0.66
10
35
A
GLY
1.00
0.41
0.53
10
36
A
HIS
0.88
0.60
0.61
10
37
A
CYS
0.95
0.64
0.50
10
38
A
GLY
0.55
0.41
0.55
10
39
A
PHE
0.60
1.00
0.69
10
40
A
LYS
0.29
0.25
0.53
8
41
A
VAL
0.45
0.56
0.76
2
42
A
GLY
0.34
0.41
0.72
5
43
A
HIS
0.66
0.60
0.58
5
44
A
GLY
0.79
0.41
0.59
5
45
A
LEU
0.68
0.70
0.58
10
48
A
TRP
0.80
0.99
0.43
10
50
A
ASN
0.60
0.39
0.61
10
51
A
ALA
0.62
0.38
0.67
10
53
A
PRO
0.98
0.47
0.68
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.73
10
56
A
VAL
0.76
0.56
0.48
10
57
A
GLY
0.64
0.41
0.43
6
58
A
ILE
0.66
0.64
0.28
9
59
A
ILE
0.66
0.64
0.31
9
60
A
VAL
0.50
0.56
0.58
7
61
A
GLU
0.52
0.33
0.64
4
62
A
GLY
0.75
0.41
0.79
4
63
A
GLU
0.70
0.33
0.80
4
64
A
LYS
0.71
0.25
0.77
4
65
A
CYS
0.83
0.64
0.69
4
66
A
HIS
0.57
0.60
0.76
4
67
A
SER
0.16
0.36
0.77
4
1
A
VAL
0.32
0.56
0.78
10
2
A
ARG
0.58
0.51
0.59
10
3
A
ASP
0.85
0.32
0.60
10
4
A
GLY
0.87
0.41
0.38
10
5
A
TYR
1.00
0.80
0.37
10
8
A
GLN
0.45
0.43
0.41
1
9
A
PRO
0.49
0.47
0.51
7
10
A
GLU
0.35
0.33
0.64
2
14
A
TYR
0.69
0.80
0.34
10
15
A
HIS
0.57
0.60
0.55
10
16
A
CYS
1.00
0.64
0.52
10
17
A
PHE
0.29
1.00
0.71
10
18
A
PRO
0.49
0.47
0.79
10
19
A
GLY
0.36
0.41
0.73
10
20
A
SER
0.56
0.36
0.66
10
21
A
SER
0.25
0.36
0.77
10
22
A
GLY
0.59
0.41
0.68
10
24
A
ASP
0.69
0.32
0.63
10
25
A
THR
0.41
0.33
0.71
10
26
A
LEU
0.81
0.70
0.53
10
28
A
LYS
0.67
0.25
0.69
10
29
A
GLU
0.51
0.33
0.70
10
31
A
GLY
0.85
0.41
0.64
10
33
A
THR
0.43
0.33
0.73
9
34
A
SER
0.67
0.36
0.66
10
35
A
GLY
1.00
0.41
0.52
10
36
A
HIS
0.88
0.60
0.61
10
37
A
CYS
0.95
0.64
0.51
10
38
A
GLY
0.55
0.41
0.55
10
39
A
PHE
0.60
1.00
0.64
10
40
A
LYS
0.29
0.25
0.74
10
41
A
VAL
0.45
0.56
0.53
10
42
A
GLY
0.34
0.41
0.68
2
43
A
HIS
0.66
0.60
0.63
2
44
A
GLY
0.79
0.41
0.66
2
45
A
LEU
0.68
0.70
0.58
10
48
A
TRP
0.80
0.99
0.44
10
50
A
ASN
0.60
0.39
0.61
10
51
A
ALA
0.62
0.38
0.67
10
53
A
PRO
0.98
0.47
0.69
10
54
A
ASP
0.73
0.32
0.77
10
55
A
ASN
0.40
0.39
0.74
10
56
A
VAL
0.76
0.56
0.51
10
57
A
GLY
0.64
0.41
0.41
6
58
A
ILE
0.66
0.64
0.32
10
59
A
ILE
0.66
0.64
0.33
10
60
A
VAL
0.50
0.56
0.60
3
61
A
GLU
0.52
0.33
0.72
2
62
A
GLY
0.75
0.41
0.82
2
63
A
GLU
0.70
0.33
0.79
2
64
A
LYS
0.71
0.25
0.78
2
65
A
CYS
0.83
0.64
0.66
2
66
A
HIS
0.57
0.60
0.74
2
67
A
SER
0.16
0.36
0.75
2
1
A
VAL
0.32
0.56
0.77
10
2
A
ARG
0.58
0.51
0.61
10
3
A
ASP
0.85
0.32
0.61
10
4
A
GLY
0.87
0.41
0.39
10
5
A
TYR
1.00
0.80
0.39
10
8
A
GLN
0.45
0.43
0.43
7
9
A
PRO
0.49
0.47
0.47
7
10
A
GLU
0.35
0.33
0.61
3
13
A
VAL
0.84
0.56
0.38
10
14
A
TYR
0.69
0.80
0.32
8
15
A
HIS
0.57
0.60
0.54
9
17
A
PHE
0.29
1.00
0.72
10
18
A
PRO
0.49
0.47
0.79
10
19
A
GLY
0.36
0.41
0.80
10
20
A
SER
0.56
0.36
0.68
10
21
A
SER
0.25
0.36
0.78
10
22
A
GLY
0.59
0.41
0.68
10
24
A
ASP
0.69
0.32
0.66
10
25
A
THR
0.41
0.33
0.71
10
26
A
LEU
0.81
0.70
0.49
10
28
A
LYS
0.67
0.25
0.72
9
29
A
GLU
0.51
0.33
0.67
10
31
A
GLY
0.85
0.41
0.60
10
32
A
GLY
0.76
0.41
0.52
9
33
A
THR
0.43
0.33
0.72
10
34
A
SER
0.67
0.36
0.66
10
35
A
GLY
1.00
0.41
0.53
10
36
A
HIS
0.88
0.60
0.60
10
37
A
CYS
0.95
0.64
0.56
10
38
A
GLY
0.55
0.41
0.52
10
39
A
PHE
0.60
1.00
0.68
10
40
A
LYS
0.29
0.25
0.57
10
41
A
VAL
0.45
0.56
0.77
10
42
A
GLY
0.34
0.41
0.76
10
43
A
HIS
0.66
0.60
0.63
10
44
A
GLY
0.79
0.41
0.63
10
45
A
LEU
0.68
0.70
0.62
10
48
A
TRP
0.80
0.99
0.46
10
50
A
ASN
0.60
0.39
0.62
10
51
A
ALA
0.62
0.38
0.66
10
53
A
PRO
0.98
0.47
0.68
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.72
10
56
A
VAL
0.76
0.56
0.49
10
57
A
GLY
0.64
0.41
0.44
4
58
A
ILE
0.66
0.64
0.33
10
60
A
VAL
0.50
0.56
0.62
9
61
A
GLU
0.52
0.33
0.69
8
62
A
GLY
0.75
0.41
0.76
8
63
A
GLU
0.70
0.33
0.77
8
64
A
LYS
0.71
0.25
0.81
8
65
A
CYS
0.83
0.64
0.69
8
66
A
HIS
0.57
0.60
0.72
8
67
A
SER
0.16
0.36
0.70
8
1
A
VAL
0.32
0.56
0.76
10
2
A
ARG
0.58
0.51
0.58
10
3
A
ASP
0.85
0.32
0.59
10
4
A
GLY
0.87
0.41
0.33
10
5
A
TYR
1.00
0.80
0.31
10
8
A
GLN
0.45
0.43
0.47
7
9
A
PRO
0.49
0.47
0.51
3
10
A
GLU
0.35
0.33
0.62
5
14
A
TYR
0.69
0.80
0.32
10
15
A
HIS
0.57
0.60
0.58
10
16
A
CYS
1.00
0.64
0.49
10
17
A
PHE
0.29
1.00
0.70
10
18
A
PRO
0.49
0.47
0.78
10
19
A
GLY
0.36
0.41
0.72
10
20
A
SER
0.56
0.36
0.62
10
21
A
SER
0.25
0.36
0.76
10
22
A
GLY
0.59
0.41
0.67
10
23
A
CYS
1.00
0.64
0.44
10
24
A
ASP
0.69
0.32
0.64
10
25
A
THR
0.41
0.33
0.71
10
26
A
LEU
0.81
0.70
0.51
10
28
A
LYS
0.67
0.25
0.71
10
29
A
GLU
0.51
0.33
0.69
10
30
A
LYS
0.44
0.25
0.55
9
31
A
GLY
0.85
0.41
0.63
10
33
A
THR
0.43
0.33
0.72
10
34
A
SER
0.67
0.36
0.67
10
35
A
GLY
1.00
0.41
0.53
10
36
A
HIS
0.88
0.60
0.60
10
37
A
CYS
0.95
0.64
0.48
10
38
A
GLY
0.55
0.41
0.53
10
39
A
PHE
0.60
1.00
0.67
10
40
A
LYS
0.29
0.25
0.68
10
41
A
VAL
0.45
0.56
0.72
7
42
A
GLY
0.34
0.41
0.58
7
43
A
HIS
0.66
0.60
0.60
7
44
A
GLY
0.79
0.41
0.59
7
45
A
LEU
0.68
0.70
0.58
10
48
A
TRP
0.80
0.99
0.42
10
50
A
ASN
0.60
0.39
0.62
10
51
A
ALA
0.62
0.38
0.60
10
53
A
PRO
0.98
0.47
0.68
10
54
A
ASP
0.73
0.32
0.75
10
55
A
ASN
0.40
0.39
0.73
10
57
A
GLY
0.64
0.41
0.44
5
58
A
ILE
0.66
0.64
0.30
10
59
A
ILE
0.66
0.64
0.28
10
60
A
VAL
0.50
0.56
0.60
5
61
A
GLU
0.52
0.33
0.71
5
62
A
GLY
0.75
0.41
0.67
5
63
A
GLU
0.70
0.33
0.77
5
64
A
LYS
0.71
0.25
0.79
5
65
A
CYS
0.83
0.64
0.67
7
66
A
HIS
0.57
0.60
0.73
5
67
A
SER
0.16
0.36
0.75
5