Pre-computed interfaces

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JET2 Viewer

Pre-computed interfaces from JET2

PDB Structure: 1C3Y chain A sc2

 

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 Residue 
 Chain 
 Type 
 Evolutionary conservation
TJET 
 Physico-chemical properties
PC 
 Circular variance
CV 
 #detections 
13
A
ALA
0.40
0.38
0.48
1
14
A
CYS
0.99
0.64
0.24
10
16
A
ALA
0.30
0.38
0.56
10
17
A
GLU
0.58
0.33
0.56
10
19
A
GLY
0.75
0.41
0.42
10
20
A
VAL
0.56
0.56
0.26
2
21
A
SER
0.55
0.36
0.56
10
22
A
GLU
0.54
0.33
0.55
10
23
A
GLU
0.60
0.33
0.56
10
25
A
LEU
0.61
0.70
0.25
10
26
A
ASN
0.35
0.39
0.52
10
27
A
LYS
0.50
0.25
0.45
5
29
A
ARG
0.55
0.51
0.45
5
30
A
ASN
0.44
0.39
0.45
9
31
A
ARG
0.57
0.51
0.42
8
32
A
GLU
0.46
0.33
0.56
9
33
A
GLU
0.38
0.33
0.58
10
34
A
VAL
0.56
0.56
0.33
10
35
A
ASP
0.50
0.32
0.56
10
36
A
ASP
0.78
0.32
0.39
10
37
A
PRO
0.56
0.47
0.50
10
38
A
LYS
0.56
0.25
0.41
9
40
A
LYS
0.76
0.25
0.25
9
41
A
GLU
0.83
0.33
0.26
10
42
A
HIS
0.73
0.60
0.14
1
44
A
PHE
0.44
1.00
0.17
10
45
A
CYS
1.00
0.64
0.12
10
46
A
ILE
0.57
0.64
0.26
10
48
A
LYS
0.60
0.25
0.34
2
49
A
ARG
0.70
0.51
0.38
10
51
A
GLY
0.65
0.41
0.41
4
52
A
PHE
0.49
1.00
0.22
4
53
A
ILE
0.47
0.64
0.19
2
54
A
ASP
0.58
0.32
0.50
2
55
A
ALA
0.36
0.38
0.61
2
56
A
SER
0.37
0.36
0.68
1
57
A
GLY
0.81
0.41
0.47
1
58
A
GLU
0.40
0.33
0.51
1
59
A
PHE
0.49
1.00
0.38
9
60
A
GLN
0.54
0.43
0.41
1
87
A
VAL
0.44
0.56
0.41
9
88
A
LYS
0.50
0.25
0.58
9
89
A
LYS
0.57
0.25
0.47
9
90
A
ASP
0.50
0.32
0.66
9
91
A
THR
0.66
0.33
0.53
10
92
A
PRO
0.48
0.47
0.33
10
93
A
GLN
0.77
0.43
0.34
10
94
A
HIS
0.50
0.60
0.37
10
99
A
PHE
0.53
1.00
0.03
9
10
A
HIS
0.24
0.60
0.48
8
13
A
ALA
0.40
0.38
0.46
1
14
A
CYS
0.99
0.64
0.24
10
16
A
ALA
0.30
0.38
0.54
10
17
A
GLU
0.58
0.33
0.56
10
19
A
GLY
0.75
0.41
0.31
10
21
A
SER
0.55
0.36
0.50
10
22
A
GLU
0.54
0.33
0.60
10
23
A
GLU
0.60
0.33
0.57
10
25
A
LEU
0.61
0.70
0.27
10
26
A
ASN
0.35
0.39
0.48
10
27
A
LYS
0.50
0.25
0.44
1
29
A
ARG
0.55
0.51
0.52
2
30
A
ASN
0.44
0.39
0.48
4
31
A
ARG
0.57
0.51
0.49
2
32
A
GLU
0.46
0.33
0.59
3
33
A
GLU
0.38
0.33
0.53
10
34
A
VAL
0.56
0.56
0.29
1
35
A
ASP
0.50
0.32
0.54
9
36
A
ASP
0.78
0.32
0.39
10
37
A
PRO
0.56
0.47
0.50
10
38
A
LYS
0.56
0.25
0.44
9
40
A
LYS
0.76
0.25
0.23
9
41
A
GLU
0.83
0.33
0.25
10
42
A
HIS
0.73
0.60
0.12
3
44
A
PHE
0.44
1.00
0.16
10
45
A
CYS
1.00
0.64
0.13
10
46
A
ILE
0.57
0.64
0.29
10
48
A
LYS
0.60
0.25
0.41
9
49
A
ARG
0.70
0.51
0.36
10
50
A
ALA
0.32
0.38
0.44
10
51
A
GLY
0.65
0.41
0.46
10
52
A
PHE
0.49
1.00
0.29
10
54
A
ASP
0.58
0.32
0.50
10
55
A
ALA
0.36
0.38
0.63
10
56
A
SER
0.37
0.36
0.64
10
57
A
GLY
0.81
0.41
0.41
10
58
A
GLU
0.40
0.33
0.54
10
59
A
PHE
0.49
1.00
0.35
10
60
A
GLN
0.54
0.43
0.37
10
61
A
LEU
0.30
0.70
0.22
9
62
A
ASP
0.52
0.32
0.51
4
63
A
HIS
0.37
0.60
0.46
4
67
A
LYS
0.60
0.25
0.41
4
68
A
PHE
0.54
1.00
0.21
4
70
A
GLU
0.32
0.33
0.53
4
71
A
ASN
0.28
0.39
0.66
4
72
A
SER
0.36
0.36
0.42
4
73
A
GLU
0.23
0.33
0.63
1
87
A
VAL
0.44
0.56
0.39
10
88
A
LYS
0.50
0.25
0.54
10
89
A
LYS
0.57
0.25
0.46
10
90
A
ASP
0.50
0.32
0.66
10
91
A
THR
0.66
0.33
0.52
10
92
A
PRO
0.48
0.47
0.32
10
93
A
GLN
0.77
0.43
0.32
9
94
A
HIS
0.50
0.60
0.35
10
104
A
HIS
0.30
0.60
0.25
1
10
A
HIS
0.24
0.60
0.34
9
12
A
ASP
0.40
0.32
0.51
9
13
A
ALA
0.40
0.38
0.48
10
15
A
LYS
0.45
0.25
0.53
8
16
A
ALA
0.30
0.38
0.62
10
17
A
GLU
0.58
0.33
0.54
10
19
A
GLY
0.75
0.41
0.41
10
20
A
VAL
0.56
0.56
0.25
2
21
A
SER
0.55
0.36
0.51
10
22
A
GLU
0.54
0.33
0.58
10
23
A
GLU
0.60
0.33
0.58
10
25
A
LEU
0.61
0.70
0.26
10
26
A
ASN
0.35
0.39
0.49
8
27
A
LYS
0.50
0.25
0.49
7
29
A
ARG
0.55
0.51
0.53
7
30
A
ASN
0.44
0.39
0.56
7
31
A
ARG
0.57
0.51
0.48
7
32
A
GLU
0.46
0.33
0.55
9
34
A
VAL
0.56
0.56
0.36
10
35
A
ASP
0.50
0.32
0.48
9
36
A
ASP
0.78
0.32
0.45
10
37
A
PRO
0.56
0.47
0.55
10
38
A
LYS
0.56
0.25
0.46
10
40
A
LYS
0.76
0.25
0.29
10
41
A
GLU
0.83
0.33
0.28
10
42
A
HIS
0.73
0.60
0.14
2
44
A
PHE
0.44
1.00
0.19
10
45
A
CYS
1.00
0.64
0.13
10
46
A
ILE
0.57
0.64
0.28
10
48
A
LYS
0.60
0.25
0.38
10
49
A
ARG
0.70
0.51
0.30
10
50
A
ALA
0.32
0.38
0.40
10
51
A
GLY
0.65
0.41
0.44
10
52
A
PHE
0.49
1.00
0.25
10
53
A
ILE
0.47
0.64
0.23
10
54
A
ASP
0.58
0.32
0.53
10
55
A
ALA
0.36
0.38
0.67
10
56
A
SER
0.37
0.36
0.66
10
57
A
GLY
0.81
0.41
0.40
10
58
A
GLU
0.40
0.33
0.51
10
59
A
PHE
0.49
1.00
0.37
10
60
A
GLN
0.54
0.43
0.40
10
63
A
HIS
0.37
0.60
0.46
6
87
A
VAL
0.44
0.56
0.38
9
88
A
LYS
0.50
0.25
0.56
8
89
A
LYS
0.57
0.25
0.44
8
90
A
ASP
0.50
0.32
0.65
10
91
A
THR
0.66
0.33
0.52
10
92
A
PRO
0.48
0.47
0.35
10
93
A
GLN
0.77
0.43
0.37
10
94
A
HIS
0.50
0.60
0.37
10
104
A
HIS
0.30
0.60
0.23
3
108
A
SER
0.23
0.36
0.55
1
9
A
GLN
0.33
0.43
0.44
3
10
A
HIS
0.24
0.60
0.53
3
11
A
SER
0.57
0.36
0.30
1
14
A
CYS
0.99
0.64
0.23
10
15
A
LYS
0.45
0.25
0.49
8
16
A
ALA
0.30
0.38
0.61
10
17
A
GLU
0.58
0.33
0.60
10
19
A
GLY
0.75
0.41
0.43
10
21
A
SER
0.55
0.36
0.48
10
22
A
GLU
0.54
0.33
0.61
10
23
A
GLU
0.60
0.33
0.55
10
25
A
LEU
0.61
0.70
0.29
10
26
A
ASN
0.35
0.39
0.48
10
27
A
LYS
0.50
0.25
0.46
5
29
A
ARG
0.55
0.51
0.56
6
30
A
ASN
0.44
0.39
0.51
9
31
A
ARG
0.57
0.51
0.44
9
32
A
GLU
0.46
0.33
0.58
9
33
A
GLU
0.38
0.33
0.56
10
34
A
VAL
0.56
0.56
0.34
2
35
A
ASP
0.50
0.32
0.58
10
36
A
ASP
0.78
0.32
0.41
10
37
A
PRO
0.56
0.47
0.48
10
38
A
LYS
0.56
0.25
0.42
10
40
A
LYS
0.76
0.25
0.24
7
41
A
GLU
0.83
0.33
0.26
10
42
A
HIS
0.73
0.60
0.16
8
44
A
PHE
0.44
1.00
0.16
10
45
A
CYS
1.00
0.64
0.11
10
46
A
ILE
0.57
0.64
0.32
10
47
A
LEU
0.57
0.70
0.15
10
48
A
LYS
0.60
0.25
0.32
2
49
A
ARG
0.70
0.51
0.35
10
50
A
ALA
0.32
0.38
0.44
10
51
A
GLY
0.65
0.41
0.44
7
52
A
PHE
0.49
1.00
0.26
7
53
A
ILE
0.47
0.64
0.19
10
54
A
ASP
0.58
0.32
0.49
6
55
A
ALA
0.36
0.38
0.59
6
56
A
SER
0.37
0.36
0.65
6
57
A
GLY
0.81
0.41
0.41
6
58
A
GLU
0.40
0.33
0.52
6
59
A
PHE
0.49
1.00
0.36
9
60
A
GLN
0.54
0.43
0.40
6
61
A
LEU
0.30
0.70
0.26
1
87
A
VAL
0.44
0.56
0.39
6
88
A
LYS
0.50
0.25
0.55
3
89
A
LYS
0.57
0.25
0.45
5
90
A
ASP
0.50
0.32
0.64
9
91
A
THR
0.66
0.33
0.50
9
92
A
PRO
0.48
0.47
0.33
1
93
A
GLN
0.77
0.43
0.34
9
94
A
HIS
0.50
0.60
0.35
9
107
A
ARG
0.27
0.51
0.53
2
108
A
SER
0.23
0.36
0.61
2
7
A
LEU
0.44
0.70
0.46
3
10
A
HIS
0.24
0.60
0.41
3
14
A
CYS
0.99
0.64
0.25
10
15
A
LYS
0.45
0.25
0.48
5
16
A
ALA
0.30
0.38
0.62
10
17
A
GLU
0.58
0.33
0.55
10
18
A
SER
0.55
0.36
0.27
4
19
A
GLY
0.75
0.41
0.46
10
20
A
VAL
0.56
0.56
0.28
10
21
A
SER
0.55
0.36
0.55
10
22
A
GLU
0.54
0.33
0.49
10
23
A
GLU
0.60
0.33
0.55
10
25
A
LEU
0.61
0.70
0.24
10
26
A
ASN
0.35
0.39
0.52
10
27
A
LYS
0.50
0.25
0.50
6
29
A
ARG
0.55
0.51
0.54
6
30
A
ASN
0.44
0.39
0.53
7
31
A
ARG
0.57
0.51
0.55
6
32
A
GLU
0.46
0.33
0.60
8
34
A
VAL
0.56
0.56
0.47
10
35
A
ASP
0.50
0.32
0.48
7
36
A
ASP
0.78
0.32
0.43
10
37
A
PRO
0.56
0.47
0.52
10
38
A
LYS
0.56
0.25
0.44
10
40
A
LYS
0.76
0.25
0.29
10
41
A
GLU
0.83
0.33
0.29
10
42
A
HIS
0.73
0.60
0.16
6
44
A
PHE
0.44
1.00
0.20
10
45
A
CYS
1.00
0.64
0.14
10
46
A
ILE
0.57
0.64
0.28
10
47
A
LEU
0.57
0.70
0.10
10
48
A
LYS
0.60
0.25
0.35
8
49
A
ARG
0.70
0.51
0.33
10
51
A
GLY
0.65
0.41
0.44
9
52
A
PHE
0.49
1.00
0.25
9
54
A
ASP
0.58
0.32
0.51
8
55
A
ALA
0.36
0.38
0.63
8
56
A
SER
0.37
0.36
0.69
8
57
A
GLY
0.81
0.41
0.47
8
58
A
GLU
0.40
0.33
0.49
8
59
A
PHE
0.49
1.00
0.37
10
60
A
GLN
0.54
0.43
0.39
8
61
A
LEU
0.30
0.70
0.27
4
87
A
VAL
0.44
0.56
0.39
7
88
A
LYS
0.50
0.25
0.57
8
89
A
LYS
0.57
0.25
0.44
7
90
A
ASP
0.50
0.32
0.65
10
91
A
THR
0.66
0.33
0.53
10
92
A
PRO
0.48
0.47
0.36
10
93
A
GLN
0.77
0.43
0.33
10
94
A
HIS
0.50
0.60
0.36
10
99
A
PHE
0.53
1.00
0.06
7
100
A
PHE
0.33
1.00
0.21
1
104
A
HIS
0.30
0.60
0.29
4
10
A
HIS
0.24
0.60
0.41
10
14
A
CYS
0.99
0.64
0.18
10
15
A
LYS
0.45
0.25
0.44
1
16
A
ALA
0.30
0.38
0.56
10
17
A
GLU
0.58
0.33
0.57
10
18
A
SER
0.55
0.36
0.24
1
19
A
GLY
0.75
0.41
0.38
10
21
A
SER
0.55
0.36
0.51
10
22
A
GLU
0.54
0.33
0.60
10
23
A
GLU
0.60
0.33
0.58
10
25
A
LEU
0.61
0.70
0.29
10
26
A
ASN
0.35
0.39
0.52
8
27
A
LYS
0.50
0.25
0.48
5
29
A
ARG
0.55
0.51
0.55
6
30
A
ASN
0.44
0.39
0.48
6
31
A
ARG
0.57
0.51
0.46
5
32
A
GLU
0.46
0.33
0.51
7
34
A
VAL
0.56
0.56
0.39
10
35
A
ASP
0.50
0.32
0.39
1
36
A
ASP
0.78
0.32
0.41
10
37
A
PRO
0.56
0.47
0.52
10
38
A
LYS
0.56
0.25
0.44
10
40
A
LYS
0.76
0.25
0.22
6
41
A
GLU
0.83
0.33
0.27
10
42
A
HIS
0.73
0.60
0.18
6
44
A
PHE
0.44
1.00
0.18
10
45
A
CYS
1.00
0.64
0.12
10
46
A
ILE
0.57
0.64
0.33
10
48
A
LYS
0.60
0.25
0.36
9
49
A
ARG
0.70
0.51
0.31
10
50
A
ALA
0.32
0.38
0.44
10
51
A
GLY
0.65
0.41
0.46
10
52
A
PHE
0.49
1.00
0.26
10
54
A
ASP
0.58
0.32
0.52
9
55
A
ALA
0.36
0.38
0.65
9
56
A
SER
0.37
0.36
0.66
9
57
A
GLY
0.81
0.41
0.42
9
58
A
GLU
0.40
0.33
0.53
9
59
A
PHE
0.49
1.00
0.37
10
60
A
GLN
0.54
0.43
0.40
8
61
A
LEU
0.30
0.70
0.30
1
62
A
ASP
0.52
0.32
0.54
1
63
A
HIS
0.37
0.60
0.48
5
87
A
VAL
0.44
0.56
0.42
8
88
A
LYS
0.50
0.25
0.58
8
89
A
LYS
0.57
0.25
0.46
8
90
A
ASP
0.50
0.32
0.65
10
91
A
THR
0.66
0.33
0.51
10
92
A
PRO
0.48
0.47
0.33
10
93
A
GLN
0.77
0.43
0.29
10
94
A
HIS
0.50
0.60
0.32
10
100
A
PHE
0.33
1.00
0.22
4
104
A
HIS
0.30
0.60
0.25
3
107
A
ARG
0.27
0.51
0.54
1
8
A
LYS
0.31
0.25
0.54
1
9
A
GLN
0.33
0.43
0.47
1
10
A
HIS
0.24
0.60
0.36
4
13
A
ALA
0.40
0.38
0.50
10
14
A
CYS
0.99
0.64
0.29
10
15
A
LYS
0.45
0.25
0.47
2
16
A
ALA
0.30
0.38
0.64
10
17
A
GLU
0.58
0.33
0.56
10
19
A
GLY
0.75
0.41
0.31
10
21
A
SER
0.55
0.36
0.46
10
22
A
GLU
0.54
0.33
0.54
10
23
A
GLU
0.60
0.33
0.55
10
25
A
LEU
0.61
0.70
0.25
10
26
A
ASN
0.35
0.39
0.49
10
30
A
ASN
0.44
0.39
0.48
4
31
A
ARG
0.57
0.51
0.50
4
32
A
GLU
0.46
0.33
0.56
4
33
A
GLU
0.38
0.33
0.52
10
34
A
VAL
0.56
0.56
0.34
2
35
A
ASP
0.50
0.32
0.59
10
36
A
ASP
0.78
0.32
0.41
10
37
A
PRO
0.56
0.47
0.50
10
38
A
LYS
0.56
0.25
0.42
10
40
A
LYS
0.76
0.25
0.23
9
41
A
GLU
0.83
0.33
0.26
10
42
A
HIS
0.73
0.60
0.09
1
44
A
PHE
0.44
1.00
0.19
10
45
A
CYS
1.00
0.64
0.18
10
48
A
LYS
0.60
0.25
0.37
8
49
A
ARG
0.70
0.51
0.27
1
51
A
GLY
0.65
0.41
0.44
8
52
A
PHE
0.49
1.00
0.22
9
54
A
ASP
0.58
0.32
0.48
9
55
A
ALA
0.36
0.38
0.54
9
56
A
SER
0.37
0.36
0.66
9
57
A
GLY
0.81
0.41
0.48
9
58
A
GLU
0.40
0.33
0.50
9
59
A
PHE
0.49
1.00
0.37
10
60
A
GLN
0.54
0.43
0.39
9
61
A
LEU
0.30
0.70
0.28
9
63
A
HIS
0.37
0.60
0.45
7
87
A
VAL
0.44
0.56
0.39
10
88
A
LYS
0.50
0.25
0.57
10
89
A
LYS
0.57
0.25
0.46
10
90
A
ASP
0.50
0.32
0.64
10
91
A
THR
0.66
0.33
0.54
10
92
A
PRO
0.48
0.47
0.38
10
93
A
GLN
0.77
0.43
0.34
10
94
A
HIS
0.50
0.60
0.34
10
13
A
ALA
0.40
0.38
0.48
10
15
A
LYS
0.45
0.25
0.55
9
16
A
ALA
0.30
0.38
0.63
10
17
A
GLU
0.58
0.33
0.56
10
18
A
SER
0.55
0.36
0.26
3
19
A
GLY
0.75
0.41
0.44
10
20
A
VAL
0.56
0.56
0.27
10
21
A
SER
0.55
0.36
0.53
10
22
A
GLU
0.54
0.33
0.48
10
23
A
GLU
0.60
0.33
0.55
10
25
A
LEU
0.61
0.70
0.24
10
26
A
ASN
0.35
0.39
0.51
10
27
A
LYS
0.50
0.25
0.48
10
29
A
ARG
0.55
0.51
0.55
10
30
A
ASN
0.44
0.39
0.54
10
31
A
ARG
0.57
0.51
0.48
10
32
A
GLU
0.46
0.33
0.51
10
34
A
VAL
0.56
0.56
0.41
10
35
A
ASP
0.50
0.32
0.47
6
36
A
ASP
0.78
0.32
0.46
10
37
A
PRO
0.56
0.47
0.53
10
38
A
LYS
0.56
0.25
0.44
10
40
A
LYS
0.76
0.25
0.30
10
41
A
GLU
0.83
0.33
0.28
10
42
A
HIS
0.73
0.60
0.13
8
44
A
PHE
0.44
1.00
0.16
10
45
A
CYS
1.00
0.64
0.12
10
46
A
ILE
0.57
0.64
0.24
10
48
A
LYS
0.60
0.25
0.33
5
51
A
GLY
0.65
0.41
0.33
1
52
A
PHE
0.49
1.00
0.25
5
54
A
ASP
0.58
0.32
0.48
6
55
A
ALA
0.36
0.38
0.61
6
56
A
SER
0.37
0.36
0.68
6
57
A
GLY
0.81
0.41
0.45
6
58
A
GLU
0.40
0.33
0.51
6
59
A
PHE
0.49
1.00
0.32
9
60
A
GLN
0.54
0.43
0.38
5
61
A
LEU
0.30
0.70
0.26
1
62
A
ASP
0.52
0.32
0.52
1
63
A
HIS
0.37
0.60
0.43
1
66
A
THR
0.39
0.33
0.45
1
67
A
LYS
0.60
0.25
0.41
1
68
A
PHE
0.54
1.00
0.23
1
70
A
GLU
0.32
0.33
0.56
1
71
A
ASN
0.28
0.39
0.68
1
72
A
SER
0.36
0.36
0.48
1
81
A
LEU
0.53
0.70
0.23
1
84
A
LYS
0.60
0.25
0.55
2
87
A
VAL
0.44
0.56
0.42
9
88
A
LYS
0.50
0.25
0.58
9
89
A
LYS
0.57
0.25
0.48
9
90
A
ASP
0.50
0.32
0.66
9
91
A
THR
0.66
0.33
0.53
10
92
A
PRO
0.48
0.47
0.36
10
93
A
GLN
0.77
0.43
0.35
10
94
A
HIS
0.50
0.60
0.36
10
104
A
HIS
0.30
0.60
0.23
2
107
A
ARG
0.27
0.51
0.57
2
108
A
SER
0.23
0.36
0.54
2
10
A
HIS
0.24
0.60
0.33
10
13
A
ALA
0.40
0.38
0.52
10
14
A
CYS
0.99
0.64
0.27
10
15
A
LYS
0.45
0.25
0.49
8
16
A
ALA
0.30
0.38
0.62
10
17
A
GLU
0.58
0.33
0.57
10
19
A
GLY
0.75
0.41
0.38
10
21
A
SER
0.55
0.36
0.48
10
22
A
GLU
0.54
0.33
0.56
10
23
A
GLU
0.60
0.33
0.58
10
25
A
LEU
0.61
0.70
0.28
10
26
A
ASN
0.35
0.39
0.51
10
27
A
LYS
0.50
0.25
0.43
8
29
A
ARG
0.55
0.51
0.47
8
30
A
ASN
0.44
0.39
0.48
10
31
A
ARG
0.57
0.51
0.53
10
32
A
GLU
0.46
0.33
0.58
10
33
A
GLU
0.38
0.33
0.53
10
34
A
VAL
0.56
0.56
0.33
1
35
A
ASP
0.50
0.32
0.51
10
36
A
ASP
0.78
0.32
0.41
10
37
A
PRO
0.56
0.47
0.52
10
38
A
LYS
0.56
0.25
0.43
10
40
A
LYS
0.76
0.25
0.27
10
41
A
GLU
0.83
0.33
0.28
10
42
A
HIS
0.73
0.60
0.10
1
44
A
PHE
0.44
1.00
0.19
10
45
A
CYS
1.00
0.64
0.13
10
46
A
ILE
0.57
0.64
0.24
10
47
A
LEU
0.57
0.70
0.08
10
48
A
LYS
0.60
0.25
0.38
7
49
A
ARG
0.70
0.51
0.34
10
50
A
ALA
0.32
0.38
0.39
10
51
A
GLY
0.65
0.41
0.45
8
52
A
PHE
0.49
1.00
0.26
8
54
A
ASP
0.58
0.32
0.50
7
55
A
ALA
0.36
0.38
0.63
7
56
A
SER
0.37
0.36
0.65
7
57
A
GLY
0.81
0.41
0.40
7
58
A
GLU
0.40
0.33
0.51
7
59
A
PHE
0.49
1.00
0.37
9
60
A
GLN
0.54
0.43
0.41
7
61
A
LEU
0.30
0.70
0.26
4
62
A
ASP
0.52
0.32
0.52
1
63
A
HIS
0.37
0.60
0.47
1
66
A
THR
0.39
0.33
0.45
1
87
A
VAL
0.44
0.56
0.40
6
88
A
LYS
0.50
0.25
0.58
6
89
A
LYS
0.57
0.25
0.43
6
90
A
ASP
0.50
0.32
0.64
6
91
A
THR
0.66
0.33
0.50
6
93
A
GLN
0.77
0.43
0.34
9
94
A
HIS
0.50
0.60
0.35
10
104
A
HIS
0.30
0.60
0.29
2
107
A
ARG
0.27
0.51
0.47
2
10
A
HIS
0.24
0.60
0.33
10
12
A
ASP
0.40
0.32
0.54
10
13
A
ALA
0.40
0.38
0.49
10
14
A
CYS
0.99
0.64
0.26
10
16
A
ALA
0.30
0.38
0.62
10
17
A
GLU
0.58
0.33
0.61
10
19
A
GLY
0.75
0.41
0.35
10
20
A
VAL
0.56
0.56
0.23
1
21
A
SER
0.55
0.36
0.41
10
22
A
GLU
0.54
0.33
0.48
10
23
A
GLU
0.60
0.33
0.59
10
25
A
LEU
0.61
0.70
0.27
10
26
A
ASN
0.35
0.39
0.49
6
27
A
LYS
0.50
0.25
0.48
4
29
A
ARG
0.55
0.51
0.56
4
30
A
ASN
0.44
0.39
0.51
4
31
A
ARG
0.57
0.51
0.48
4
32
A
GLU
0.46
0.33
0.54
6
34
A
VAL
0.56
0.56
0.42
10
35
A
ASP
0.50
0.32
0.56
10
36
A
ASP
0.78
0.32
0.44
10
37
A
PRO
0.56
0.47
0.52
10
38
A
LYS
0.56
0.25
0.43
10
40
A
LYS
0.76
0.25
0.25
10
41
A
GLU
0.83
0.33
0.27
10
42
A
HIS
0.73
0.60
0.12
4
44
A
PHE
0.44
1.00
0.16
10
45
A
CYS
1.00
0.64
0.15
10
46
A
ILE
0.57
0.64
0.28
10
48
A
LYS
0.60
0.25
0.39
8
49
A
ARG
0.70
0.51
0.46
10
50
A
ALA
0.32
0.38
0.42
10
51
A
GLY
0.65
0.41
0.45
10
52
A
PHE
0.49
1.00
0.28
10
53
A
ILE
0.47
0.64
0.20
10
54
A
ASP
0.58
0.32
0.51
8
55
A
ALA
0.36
0.38
0.61
8
56
A
SER
0.37
0.36
0.67
7
57
A
GLY
0.81
0.41
0.45
7
58
A
GLU
0.40
0.33
0.48
7
59
A
PHE
0.49
1.00
0.36
9
60
A
GLN
0.54
0.43
0.41
6
61
A
LEU
0.30
0.70
0.29
1
63
A
HIS
0.37
0.60
0.47
6
87
A
VAL
0.44
0.56
0.40
9
88
A
LYS
0.50
0.25
0.59
9
89
A
LYS
0.57
0.25
0.43
8
90
A
ASP
0.50
0.32
0.64
9
91
A
THR
0.66
0.33
0.52
8
92
A
PRO
0.48
0.47
0.34
10
93
A
GLN
0.77
0.43
0.34
10
94
A
HIS
0.50
0.60
0.37
10
13
A
ALA
0.40
0.38
0.48
10
14
A
CYS
0.99
0.64
0.27
10
15
A
LYS
0.45
0.25
0.47
3
16
A
ALA
0.30
0.38
0.65
10
17
A
GLU
0.58
0.33
0.60
10
19
A
GLY
0.75
0.41
0.46
10
20
A
VAL
0.56
0.56
0.28
3
21
A
SER
0.55
0.36
0.60
10
22
A
GLU
0.54
0.33
0.52
10
23
A
GLU
0.60
0.33
0.53
10
25
A
LEU
0.61
0.70
0.26
10
26
A
ASN
0.35
0.39
0.51
10
27
A
LYS
0.50
0.25
0.49
10
29
A
ARG
0.55
0.51
0.55
10
30
A
ASN
0.44
0.39
0.50
10
31
A
ARG
0.57
0.51
0.53
10
34
A
VAL
0.56
0.56
0.47
10
35
A
ASP
0.50
0.32
0.55
10
36
A
ASP
0.78
0.32
0.39
10
37
A
PRO
0.56
0.47
0.50
10
38
A
LYS
0.56
0.25
0.42
10
40
A
LYS
0.76
0.25
0.25
8
41
A
GLU
0.83
0.33
0.26
10
42
A
HIS
0.73
0.60
0.15
2
44
A
PHE
0.44
1.00
0.18
10
45
A
CYS
1.00
0.64
0.14
10
46
A
ILE
0.57
0.64
0.28
10
47
A
LEU
0.57
0.70
0.13
10
48
A
LYS
0.60
0.25
0.39
6
49
A
ARG
0.70
0.51
0.36
10
51
A
GLY
0.65
0.41
0.44
7
52
A
PHE
0.49
1.00
0.25
8
54
A
ASP
0.58
0.32
0.50
7
55
A
ALA
0.36
0.38
0.65
7
56
A
SER
0.37
0.36
0.68
7
57
A
GLY
0.81
0.41
0.44
7
58
A
GLU
0.40
0.33
0.55
7
59
A
PHE
0.49
1.00
0.39
7
60
A
GLN
0.54
0.43
0.39
8
61
A
LEU
0.30
0.70
0.28
3
63
A
HIS
0.37
0.60
0.47
4
87
A
VAL
0.44
0.56
0.40
5
88
A
LYS
0.50
0.25
0.57
5
89
A
LYS
0.57
0.25
0.47
5
90
A
ASP
0.50
0.32
0.65
5
91
A
THR
0.66
0.33
0.54
9
92
A
PRO
0.48
0.47
0.36
9
93
A
GLN
0.77
0.43
0.29
8
94
A
HIS
0.50
0.60
0.35
10
99
A
PHE
0.53
1.00
0.05
5
104
A
HIS
0.30
0.60
0.28
5
107
A
ARG
0.27
0.51
0.56
3
108
A
SER
0.23
0.36
0.56
3
10
A
HIS
0.24
0.60
0.36
10
11
A
SER
0.57
0.36
0.38
10
12
A
ASP
0.40
0.32
0.53
10
13
A
ALA
0.40
0.38
0.47
10
14
A
CYS
0.99
0.64
0.27
10
15
A
LYS
0.45
0.25
0.54
10
16
A
ALA
0.30
0.38
0.61
10
17
A
GLU
0.58
0.33
0.59
10
19
A
GLY
0.75
0.41
0.40
10
20
A
VAL
0.56
0.56
0.29
10
21
A
SER
0.55
0.36
0.60
10
22
A
GLU
0.54
0.33
0.55
10
23
A
GLU
0.60
0.33
0.57
10
25
A
LEU
0.61
0.70
0.27
10
26
A
ASN
0.35
0.39
0.51
10
27
A
LYS
0.50
0.25
0.45
10
29
A
ARG
0.55
0.51
0.52
10
30
A
ASN
0.44
0.39
0.50
10
31
A
ARG
0.57
0.51
0.46
7
32
A
GLU
0.46
0.33
0.61
10
33
A
GLU
0.38
0.33
0.59
10
34
A
VAL
0.56
0.56
0.34
10
35
A
ASP
0.50
0.32
0.55
9
36
A
ASP
0.78
0.32
0.41
10
37
A
PRO
0.56
0.47
0.50
10
38
A
LYS
0.56
0.25
0.42
9
40
A
LYS
0.76
0.25
0.28
10
41
A
GLU
0.83
0.33
0.26
10
42
A
HIS
0.73
0.60
0.19
10
44
A
PHE
0.44
1.00
0.16
10
45
A
CYS
1.00
0.64
0.11
10
46
A
ILE
0.57
0.64
0.31
10
47
A
LEU
0.57
0.70
0.14
10
49
A
ARG
0.70
0.51
0.32
2
51
A
GLY
0.65
0.41
0.36
1
52
A
PHE
0.49
1.00
0.26
3
53
A
ILE
0.47
0.64
0.17
1
59
A
PHE
0.49
1.00
0.36
5
63
A
HIS
0.37
0.60
0.49
1
87
A
VAL
0.44
0.56
0.40
5
88
A
LYS
0.50
0.25
0.57
2
89
A
LYS
0.57
0.25
0.49
5
90
A
ASP
0.50
0.32
0.59
7
91
A
THR
0.66
0.33
0.52
7
93
A
GLN
0.77
0.43
0.33
9
94
A
HIS
0.50
0.60
0.38
10
100
A
PHE
0.33
1.00
0.19
2
104
A
HIS
0.30
0.60
0.25
3
107
A
ARG
0.27
0.51
0.53
1
10
A
HIS
0.24
0.60
0.33
10
14
A
CYS
0.99
0.64
0.25
10
15
A
LYS
0.45
0.25
0.46
6
16
A
ALA
0.30
0.38
0.61
10
17
A
GLU
0.58
0.33
0.60
10
19
A
GLY
0.75
0.41
0.41
10
21
A
SER
0.55
0.36
0.48
10
22
A
GLU
0.54
0.33
0.60
10
23
A
GLU
0.60
0.33
0.57
10
25
A
LEU
0.61
0.70
0.27
10
26
A
ASN
0.35
0.39
0.49
10
27
A
LYS
0.50
0.25
0.47
9
29
A
ARG
0.55
0.51
0.54
10
30
A
ASN
0.44
0.39
0.51
10
31
A
ARG
0.57
0.51
0.49
10
32
A
GLU
0.46
0.33
0.58
10
33
A
GLU
0.38
0.33
0.59
10
34
A
VAL
0.56
0.56
0.40
10
35
A
ASP
0.50
0.32
0.57
10
36
A
ASP
0.78
0.32
0.41
10
37
A
PRO
0.56
0.47
0.52
10
38
A
LYS
0.56
0.25
0.42
10
40
A
LYS
0.76
0.25
0.27
10
41
A
GLU
0.83
0.33
0.26
10
42
A
HIS
0.73
0.60
0.16
8
44
A
PHE
0.44
1.00
0.14
10
46
A
ILE
0.57
0.64
0.32
10
48
A
LYS
0.60
0.25
0.30
5
49
A
ARG
0.70
0.51
0.36
6
50
A
ALA
0.32
0.38
0.42
6
51
A
GLY
0.65
0.41
0.45
6
52
A
PHE
0.49
1.00
0.26
6
53
A
ILE
0.47
0.64
0.20
10
54
A
ASP
0.58
0.32
0.50
6
55
A
ALA
0.36
0.38
0.57
6
56
A
SER
0.37
0.36
0.69
6
57
A
GLY
0.81
0.41
0.45
6
58
A
GLU
0.40
0.33
0.49
6
59
A
PHE
0.49
1.00
0.37
9
60
A
GLN
0.54
0.43
0.40
5
61
A
LEU
0.30
0.70
0.29
4
63
A
HIS
0.37
0.60
0.47
3
87
A
VAL
0.44
0.56
0.39
8
88
A
LYS
0.50
0.25
0.57
8
89
A
LYS
0.57
0.25
0.47
8
90
A
ASP
0.50
0.32
0.64
10
91
A
THR
0.66
0.33
0.50
9
92
A
PRO
0.48
0.47
0.33
1
93
A
GLN
0.77
0.43
0.33
10
94
A
HIS
0.50
0.60
0.35
10
100
A
PHE
0.33
1.00
0.20
3
108
A
SER
0.23
0.36
0.64
2
13
A
ALA
0.40
0.38
0.53
10
14
A
CYS
0.99
0.64
0.28
10
16
A
ALA
0.30
0.38
0.64
10
17
A
GLU
0.58
0.33
0.57
10
18
A
SER
0.55
0.36
0.26
2
19
A
GLY
0.75
0.41
0.37
10
20
A
VAL
0.56
0.56
0.27
4
21
A
SER
0.55
0.36
0.53
10
22
A
GLU
0.54
0.33
0.57
10
23
A
GLU
0.60
0.33
0.53
10
25
A
LEU
0.61
0.70
0.28
10
26
A
ASN
0.35
0.39
0.50
10
27
A
LYS
0.50
0.25
0.48
6
29
A
ARG
0.55
0.51
0.51
6
30
A
ASN
0.44
0.39
0.48
6
31
A
ARG
0.57
0.51
0.49
6
32
A
GLU
0.46
0.33
0.54
7
33
A
GLU
0.38
0.33
0.54
10
34
A
VAL
0.56
0.56
0.38
10
35
A
ASP
0.50
0.32
0.48
9
36
A
ASP
0.78
0.32
0.42
10
37
A
PRO
0.56
0.47
0.52
10
38
A
LYS
0.56
0.25
0.46
10
40
A
LYS
0.76
0.25
0.27
10
41
A
GLU
0.83
0.33
0.26
10
42
A
HIS
0.73
0.60
0.15
5
44
A
PHE
0.44
1.00
0.19
10
45
A
CYS
1.00
0.64
0.15
10
46
A
ILE
0.57
0.64
0.30
10
47
A
LEU
0.57
0.70
0.14
10
48
A
LYS
0.60
0.25
0.36
8
49
A
ARG
0.70
0.51
0.45
10
50
A
ALA
0.32
0.38
0.42
10
51
A
GLY
0.65
0.41
0.45
9
52
A
PHE
0.49
1.00
0.24
9
54
A
ASP
0.58
0.32
0.52
8
55
A
ALA
0.36
0.38
0.64
8
56
A
SER
0.37
0.36
0.66
8
57
A
GLY
0.81
0.41
0.42
8
58
A
GLU
0.40
0.33
0.55
8
59
A
PHE
0.49
1.00
0.39
10
60
A
GLN
0.54
0.43
0.41
9
61
A
LEU
0.30
0.70
0.30
1
62
A
ASP
0.52
0.32
0.55
1
63
A
HIS
0.37
0.60
0.48
8
87
A
VAL
0.44
0.56
0.40
10
88
A
LYS
0.50
0.25
0.57
10
89
A
LYS
0.57
0.25
0.45
10
90
A
ASP
0.50
0.32
0.66
10
91
A
THR
0.66
0.33
0.52
10
92
A
PRO
0.48
0.47
0.34
10
93
A
GLN
0.77
0.43
0.34
10
94
A
HIS
0.50
0.60
0.34
10
100
A
PHE
0.33
1.00
0.20
1
10
A
HIS
0.24
0.60
0.36
10
13
A
ALA
0.40
0.38
0.48
10
14
A
CYS
0.99
0.64
0.21
10
15
A
LYS
0.45
0.25
0.47
6
16
A
ALA
0.30
0.38
0.58
10
17
A
GLU
0.58
0.33
0.58
10
18
A
SER
0.55
0.36
0.26
6
19
A
GLY
0.75
0.41
0.42
10
20
A
VAL
0.56
0.56
0.28
10
21
A
SER
0.55
0.36
0.57
10
22
A
GLU
0.54
0.33
0.50
10
23
A
GLU
0.60
0.33
0.55
10
25
A
LEU
0.61
0.70
0.25
10
26
A
ASN
0.35
0.39
0.52
10
27
A
LYS
0.50
0.25
0.44
10
29
A
ARG
0.55
0.51
0.53
10
30
A
ASN
0.44
0.39
0.54
10
31
A
ARG
0.57
0.51
0.53
10
32
A
GLU
0.46
0.33
0.54
10
34
A
VAL
0.56
0.56
0.40
10
35
A
ASP
0.50
0.32
0.51
9
36
A
ASP
0.78
0.32
0.42
10
37
A
PRO
0.56
0.47
0.52
10
38
A
LYS
0.56
0.25
0.41
10
40
A
LYS
0.76
0.25
0.29
10
41
A
GLU
0.83
0.33
0.27
10
42
A
HIS
0.73
0.60
0.13
4
44
A
PHE
0.44
1.00
0.16
10
45
A
CYS
1.00
0.64
0.09
10
46
A
ILE
0.57
0.64
0.29
10
48
A
LYS
0.60
0.25
0.30
1
51
A
GLY
0.65
0.41
0.44
1
52
A
PHE
0.49
1.00
0.27
3
54
A
ASP
0.58
0.32
0.50
4
55
A
ALA
0.36
0.38
0.61
4
56
A
SER
0.37
0.36
0.66
4
57
A
GLY
0.81
0.41
0.42
4
58
A
GLU
0.40
0.33
0.53
4
59
A
PHE
0.49
1.00
0.39
8
60
A
GLN
0.54
0.43
0.40
2
61
A
LEU
0.30
0.70
0.24
2
62
A
ASP
0.52
0.32
0.52
2
87
A
VAL
0.44
0.56
0.40
8
88
A
LYS
0.50
0.25
0.58
8
89
A
LYS
0.57
0.25
0.48
8
90
A
ASP
0.50
0.32
0.67
8
91
A
THR
0.66
0.33
0.51
10
92
A
PRO
0.48
0.47
0.35
10
93
A
GLN
0.77
0.43
0.33
10
94
A
HIS
0.50
0.60
0.35
10
99
A
PHE
0.53
1.00
0.01
2
100
A
PHE
0.33
1.00
0.15
1
104
A
HIS
0.30
0.60
0.27
6
108
A
SER
0.23
0.36
0.55
1
8
A
LYS
0.31
0.25
0.56
2
10
A
HIS
0.24
0.60
0.36
10
14
A
CYS
0.99
0.64
0.15
10
17
A
GLU
0.58
0.33
0.56
10
19
A
GLY
0.75
0.41
0.34
10
20
A
VAL
0.56
0.56
0.26
3
21
A
SER
0.55
0.36
0.53
10
22
A
GLU
0.54
0.33
0.60
10
23
A
GLU
0.60
0.33
0.57
10
25
A
LEU
0.61
0.70
0.25
10
26
A
ASN
0.35
0.39
0.51
10
27
A
LYS
0.50
0.25
0.47
5
29
A
ARG
0.55
0.51
0.46
5
30
A
ASN
0.44
0.39
0.52
5
31
A
ARG
0.57
0.51
0.49
5
32
A
GLU
0.46
0.33
0.54
8
33
A
GLU
0.38
0.33
0.51
10
34
A
VAL
0.56
0.56
0.38
10
35
A
ASP
0.50
0.32
0.58
10
36
A
ASP
0.78
0.32
0.45
10
37
A
PRO
0.56
0.47
0.53
10
38
A
LYS
0.56
0.25
0.43
10
40
A
LYS
0.76
0.25
0.27
10
41
A
GLU
0.83
0.33
0.27
10
42
A
HIS
0.73
0.60
0.14
6
44
A
PHE
0.44
1.00
0.16
10
45
A
CYS
1.00
0.64
0.10
10
46
A
ILE
0.57
0.64
0.28
10
48
A
LYS
0.60
0.25
0.34
3
49
A
ARG
0.70
0.51
0.33
10
51
A
GLY
0.65
0.41
0.44
5
52
A
PHE
0.49
1.00
0.24
6
53
A
ILE
0.47
0.64
0.20
10
54
A
ASP
0.58
0.32
0.50
6
55
A
ALA
0.36
0.38
0.60
6
56
A
SER
0.37
0.36
0.69
6
57
A
GLY
0.81
0.41
0.46
6
58
A
GLU
0.40
0.33
0.50
6
59
A
PHE
0.49
1.00
0.38
9
60
A
GLN
0.54
0.43
0.40
4
61
A
LEU
0.30
0.70
0.24
8
63
A
HIS
0.37
0.60
0.49
1
87
A
VAL
0.44
0.56
0.39
8
88
A
LYS
0.50
0.25
0.56
10
89
A
LYS
0.57
0.25
0.46
8
90
A
ASP
0.50
0.32
0.63
9
91
A
THR
0.66
0.33
0.52
10
92
A
PRO
0.48
0.47
0.35
10
93
A
GLN
0.77
0.43
0.35
10
94
A
HIS
0.50
0.60
0.37
10
107
A
ARG
0.27
0.51
0.51
1
108
A
SER
0.23
0.36
0.59
1
10
A
HIS
0.24
0.60
0.38
7
13
A
ALA
0.40
0.38
0.46
1
14
A
CYS
0.99
0.64
0.24
10
15
A
LYS
0.45
0.25
0.42
1
16
A
ALA
0.30
0.38
0.59
10
17
A
GLU
0.58
0.33
0.60
10
19
A
GLY
0.75
0.41
0.42
10
20
A
VAL
0.56
0.56
0.25
5
21
A
SER
0.55
0.36
0.46
10
22
A
GLU
0.54
0.33
0.56
10
23
A
GLU
0.60
0.33
0.57
10
25
A
LEU
0.61
0.70
0.26
10
26
A
ASN
0.35
0.39
0.51
10
27
A
LYS
0.50
0.25
0.49
10
29
A
ARG
0.55
0.51
0.49
10
30
A
ASN
0.44
0.39
0.50
10
31
A
ARG
0.57
0.51
0.53
3
32
A
GLU
0.46
0.33
0.58
10
34
A
VAL
0.56
0.56
0.41
10
35
A
ASP
0.50
0.32
0.56
10
36
A
ASP
0.78
0.32
0.46
10
37
A
PRO
0.56
0.47
0.53
10
38
A
LYS
0.56
0.25
0.44
10
40
A
LYS
0.76
0.25
0.27
10
41
A
GLU
0.83
0.33
0.27
10
42
A
HIS
0.73
0.60
0.14
6
44
A
PHE
0.44
1.00
0.20
10
45
A
CYS
1.00
0.64
0.16
10
46
A
ILE
0.57
0.64
0.26
10
48
A
LYS
0.60
0.25
0.41
10
49
A
ARG
0.70
0.51
0.39
10
50
A
ALA
0.32
0.38
0.41
10
51
A
GLY
0.65
0.41
0.44
10
52
A
PHE
0.49
1.00
0.25
10
54
A
ASP
0.58
0.32
0.52
10
55
A
ALA
0.36
0.38
0.63
10
56
A
SER
0.37
0.36
0.64
10
57
A
GLY
0.81
0.41
0.44
10
58
A
GLU
0.40
0.33
0.55
10
59
A
PHE
0.49
1.00
0.39
10
60
A
GLN
0.54
0.43
0.39
10
61
A
LEU
0.30
0.70
0.26
3
63
A
HIS
0.37
0.60
0.46
4
87
A
VAL
0.44
0.56
0.40
10
88
A
LYS
0.50
0.25
0.56
10
89
A
LYS
0.57
0.25
0.47
10
90
A
ASP
0.50
0.32
0.68
10
91
A
THR
0.66
0.33
0.52
10
92
A
PRO
0.48
0.47
0.38
10
93
A
GLN
0.77
0.43
0.38
10
94
A
HIS
0.50
0.60
0.32
10
100
A
PHE
0.33
1.00
0.21
1
10
A
HIS
0.24
0.60
0.26
10
12
A
ASP
0.40
0.32
0.50
10
13
A
ALA
0.40
0.38
0.55
10
14
A
CYS
0.99
0.64
0.28
10
15
A
LYS
0.45
0.25
0.51
5
16
A
ALA
0.30
0.38
0.60
10
17
A
GLU
0.58
0.33
0.58
10
19
A
GLY
0.75
0.41
0.43
10
20
A
VAL
0.56
0.56
0.26
2
21
A
SER
0.55
0.36
0.58
10
22
A
GLU
0.54
0.33
0.45
5
23
A
GLU
0.60
0.33
0.57
10
25
A
LEU
0.61
0.70
0.23
10
26
A
ASN
0.35
0.39
0.50
10
27
A
LYS
0.50
0.25
0.48
10
29
A
ARG
0.55
0.51
0.49
10
30
A
ASN
0.44
0.39
0.51
10
31
A
ARG
0.57
0.51
0.55
10
32
A
GLU
0.46
0.33
0.57
10
34
A
VAL
0.56
0.56
0.38
10
35
A
ASP
0.50
0.32
0.48
6
36
A
ASP
0.78
0.32
0.43
10
37
A
PRO
0.56
0.47
0.52
10
38
A
LYS
0.56
0.25
0.42
9
40
A
LYS
0.76
0.25
0.27
10
41
A
GLU
0.83
0.33
0.29
10
42
A
HIS
0.73
0.60
0.11
1
44
A
PHE
0.44
1.00
0.19
10
45
A
CYS
1.00
0.64
0.14
10
46
A
ILE
0.57
0.64
0.25
10
48
A
LYS
0.60
0.25
0.40
8
49
A
ARG
0.70
0.51
0.45
10
50
A
ALA
0.32
0.38
0.44
10
51
A
GLY
0.65
0.41
0.46
10
52
A
PHE
0.49
1.00
0.25
10
54
A
ASP
0.58
0.32
0.51
8
55
A
ALA
0.36
0.38
0.64
8
56
A
SER
0.37
0.36
0.67
8
57
A
GLY
0.81
0.41
0.43
8
58
A
GLU
0.40
0.33
0.55
8
59
A
PHE
0.49
1.00
0.37
10
60
A
GLN
0.54
0.43
0.41
8
61
A
LEU
0.30
0.70
0.27
6
63
A
HIS
0.37
0.60
0.47
7
87
A
VAL
0.44
0.56
0.36
10
88
A
LYS
0.50
0.25
0.53
10
89
A
LYS
0.57
0.25
0.48
10
90
A
ASP
0.50
0.32
0.66
10
91
A
THR
0.66
0.33
0.54
10
92
A
PRO
0.48
0.47
0.37
10
93
A
GLN
0.77
0.43
0.35
10
94
A
HIS
0.50
0.60
0.35
10
9
A
GLN
0.33
0.43
0.36
8
13
A
ALA
0.40
0.38
0.47
10
14
A
CYS
0.99
0.64
0.25
10
16
A
ALA
0.30
0.38
0.63
10
17
A
GLU
0.58
0.33
0.60
10
19
A
GLY
0.75
0.41
0.28
10
20
A
VAL
0.56
0.56
0.23
2
21
A
SER
0.55
0.36
0.40
6
23
A
GLU
0.60
0.33
0.53
9
25
A
LEU
0.61
0.70
0.26
8
26
A
ASN
0.35
0.39
0.51
8
27
A
LYS
0.50
0.25
0.51
8
29
A
ARG
0.55
0.51
0.45
8
30
A
ASN
0.44
0.39
0.45
8
31
A
ARG
0.57
0.51
0.55
7
32
A
GLU
0.46
0.33
0.59
9
33
A
GLU
0.38
0.33
0.48
1
34
A
VAL
0.56
0.56
0.48
10
35
A
ASP
0.50
0.32
0.51
9
36
A
ASP
0.78
0.32
0.42
10
37
A
PRO
0.56
0.47
0.52
10
38
A
LYS
0.56
0.25
0.39
10
40
A
LYS
0.76
0.25
0.30
10
41
A
GLU
0.83
0.33
0.28
10
44
A
PHE
0.44
1.00
0.19
10
45
A
CYS
1.00
0.64
0.15
10
46
A
ILE
0.57
0.64
0.28
10
47
A
LEU
0.57
0.70
0.10
10
48
A
LYS
0.60
0.25
0.36
9
49
A
ARG
0.70
0.51
0.43
10
50
A
ALA
0.32
0.38
0.42
10
51
A
GLY
0.65
0.41
0.47
10
52
A
PHE
0.49
1.00
0.27
10
53
A
ILE
0.47
0.64
0.19
10
54
A
ASP
0.58
0.32
0.50
10
55
A
ALA
0.36
0.38
0.63
10
56
A
SER
0.37
0.36
0.66
10
57
A
GLY
0.81
0.41
0.40
10
58
A
GLU
0.40
0.33
0.54
9
59
A
PHE
0.49
1.00
0.39
10
60
A
GLN
0.54
0.43
0.40
9
61
A
LEU
0.30
0.70
0.26
6
63
A
HIS
0.37
0.60
0.50
7
87
A
VAL
0.44
0.56
0.41
9
88
A
LYS
0.50
0.25
0.57
10
89
A
LYS
0.57
0.25
0.46
8
90
A
ASP
0.50
0.32
0.63
9
91
A
THR
0.66
0.33
0.50
9
92
A
PRO
0.48
0.47
0.32
10
93
A
GLN
0.77
0.43
0.33
10
94
A
HIS
0.50
0.60
0.36
10
99
A
PHE
0.53
1.00
0.05
2
100
A
PHE
0.33
1.00
0.20
2
107
A
ARG
0.27
0.51
0.46
2
10
A
HIS
0.24
0.60
0.30
10
13
A
ALA
0.40
0.38
0.45
10
14
A
CYS
0.99
0.64
0.23
10
15
A
LYS
0.45
0.25
0.47
4
16
A
ALA
0.30
0.38
0.59
10
17
A
GLU
0.58
0.33
0.59
10
19
A
GLY
0.75
0.41
0.42
10
21
A
SER
0.55
0.36
0.52
10
22
A
GLU
0.54
0.33
0.50
10
23
A
GLU
0.60
0.33
0.54
10
25
A
LEU
0.61
0.70
0.22
10
26
A
ASN
0.35
0.39
0.51
10
27
A
LYS
0.50
0.25
0.47
9
29
A
ARG
0.55
0.51
0.50
9
30
A
ASN
0.44
0.39
0.52
9
31
A
ARG
0.57
0.51
0.48
1
32
A
GLU
0.46
0.33
0.52
10
34
A
VAL
0.56
0.56
0.47
10
35
A
ASP
0.50
0.32
0.52
9
36
A
ASP
0.78
0.32
0.42
10
37
A
PRO
0.56
0.47
0.51
10
38
A
LYS
0.56
0.25
0.41
8
40
A
LYS
0.76
0.25
0.26
7
41
A
GLU
0.83
0.33
0.28
10
44
A
PHE
0.44
1.00
0.18
10
45
A
CYS
1.00
0.64
0.11
10
46
A
ILE
0.57
0.64
0.28
10
48
A
LYS
0.60
0.25
0.35
2
49
A
ARG
0.70
0.51
0.28
1
50
A
ALA
0.32
0.38
0.44
10
51
A
GLY
0.65
0.41
0.47
3
52
A
PHE
0.49
1.00
0.27
5
54
A
ASP
0.58
0.32
0.51
6
55
A
ALA
0.36
0.38
0.60
6
56
A
SER
0.37
0.36
0.69
6
57
A
GLY
0.81
0.41
0.47
6
58
A
GLU
0.40
0.33
0.51
6
59
A
PHE
0.49
1.00
0.37
8
60
A
GLN
0.54
0.43
0.39
5
63
A
HIS
0.37
0.60
0.47
1
87
A
VAL
0.44
0.56
0.40
8
88
A
LYS
0.50
0.25
0.57
8
89
A
LYS
0.57
0.25
0.46
8
90
A
ASP
0.50
0.32
0.65
8
91
A
THR
0.66
0.33
0.55
9
92
A
PRO
0.48
0.47
0.39
9
93
A
GLN
0.77
0.43
0.36
9
94
A
HIS
0.50
0.60
0.35
9
104
A
HIS
0.30
0.60
0.25
1
13
A
ALA
0.40
0.38
0.52
10
14
A
CYS
0.99
0.64
0.26
10
15
A
LYS
0.45
0.25
0.49
3
16
A
ALA
0.30
0.38
0.62
10
17
A
GLU
0.58
0.33
0.57
10
18
A
SER
0.55
0.36
0.28
2
19
A
GLY
0.75
0.41
0.32
10
20
A
VAL
0.56
0.56
0.25
2
21
A
SER
0.55
0.36
0.57
10
22
A
GLU
0.54
0.33
0.54
10
23
A
GLU
0.60
0.33
0.55
10
25
A
LEU
0.61
0.70
0.25
10
26
A
ASN
0.35
0.39
0.49
10
27
A
LYS
0.50
0.25
0.44
8
29
A
ARG
0.55
0.51
0.55
8
30
A
ASN
0.44
0.39
0.51
9
31
A
ARG
0.57
0.51
0.43
4
32
A
GLU
0.46
0.33
0.57
9
33
A
GLU
0.38
0.33
0.59
10
34
A
VAL
0.56
0.56
0.34
10
35
A
ASP
0.50
0.32
0.53
9
36
A
ASP
0.78
0.32
0.39
10
37
A
PRO
0.56
0.47
0.50
10
38
A
LYS
0.56
0.25
0.41
9
40
A
LYS
0.76
0.25
0.25
9
41
A
GLU
0.83
0.33
0.26
10
42
A
HIS
0.73
0.60
0.13
3
44
A
PHE
0.44
1.00
0.18
10
45
A
CYS
1.00
0.64
0.15
10
46
A
ILE
0.57
0.64
0.28
10
48
A
LYS
0.60
0.25
0.41
8
49
A
ARG
0.70
0.51
0.40
10
51
A
GLY
0.65
0.41
0.42
9
52
A
PHE
0.49
1.00
0.23
9
54
A
ASP
0.58
0.32
0.49
8
55
A
ALA
0.36
0.38
0.65
8
56
A
SER
0.37
0.36
0.66
7
57
A
GLY
0.81
0.41
0.42
7
58
A
GLU
0.40
0.33
0.53
7
59
A
PHE
0.49
1.00
0.37
10
60
A
GLN
0.54
0.43
0.39
6
61
A
LEU
0.30
0.70
0.26
7
62
A
ASP
0.52
0.32
0.54
1
63
A
HIS
0.37
0.60
0.46
4
67
A
LYS
0.60
0.25
0.43
1
68
A
PHE
0.54
1.00
0.23
1
70
A
GLU
0.32
0.33
0.57
1
71
A
ASN
0.28
0.39
0.69
1
72
A
SER
0.36
0.36
0.49
1
87
A
VAL
0.44
0.56
0.39
7
88
A
LYS
0.50
0.25
0.56
7
89
A
LYS
0.57
0.25
0.47
7
90
A
ASP
0.50
0.32
0.64
7
91
A
THR
0.66
0.33
0.53
9
92
A
PRO
0.48
0.47
0.35
10
93
A
GLN
0.77
0.43
0.34
9
94
A
HIS
0.50
0.60
0.36
9
99
A
PHE
0.53
1.00
0.04
7
10
A
HIS
0.24
0.60
0.35
10
13
A
ALA
0.40
0.38
0.54
10
14
A
CYS
0.99
0.64
0.33
10
15
A
LYS
0.45
0.25
0.38
1
16
A
ALA
0.30
0.38
0.65
10
17
A
GLU
0.58
0.33
0.60
10
19
A
GLY
0.75
0.41
0.38
10
20
A
VAL
0.56
0.56
0.27
3
21
A
SER
0.55
0.36
0.54
10
22
A
GLU
0.54
0.33
0.57
10
23
A
GLU
0.60
0.33
0.57
10
25
A
LEU
0.61
0.70
0.24
10
26
A
ASN
0.35
0.39
0.49
10
27
A
LYS
0.50
0.25
0.46
3
29
A
ARG
0.55
0.51
0.56
3
30
A
ASN
0.44
0.39
0.52
3
31
A
ARG
0.57
0.51
0.50
5
32
A
GLU
0.46
0.33
0.53
5
33
A
GLU
0.38
0.33
0.48
2
34
A
VAL
0.56
0.56
0.40
10
35
A
ASP
0.50
0.32
0.64
10
36
A
ASP
0.78
0.32
0.42
10
37
A
PRO
0.56
0.47
0.51
10
38
A
LYS
0.56
0.25
0.44
10
40
A
LYS
0.76
0.25
0.26
10
41
A
GLU
0.83
0.33
0.28
10
42
A
HIS
0.73
0.60
0.14
9
44
A
PHE
0.44
1.00
0.19
10
45
A
CYS
1.00
0.64
0.15
10
46
A
ILE
0.57
0.64
0.26
10
48
A
LYS
0.60
0.25
0.40
10
49
A
ARG
0.70
0.51
0.47
10
50
A
ALA
0.32
0.38
0.38
10
51
A
GLY
0.65
0.41
0.44
10
52
A
PHE
0.49
1.00
0.26
10
53
A
ILE
0.47
0.64
0.17
10
54
A
ASP
0.58
0.32
0.46
10
55
A
ALA
0.36
0.38
0.62
10
56
A
SER
0.37
0.36
0.63
4
57
A
GLY
0.81
0.41
0.40
4
58
A
GLU
0.40
0.33
0.52
3
59
A
PHE
0.49
1.00
0.39
9
60
A
GLN
0.54
0.43
0.39
7
61
A
LEU
0.30
0.70
0.24
1
62
A
ASP
0.52
0.32
0.53
1
63
A
HIS
0.37
0.60
0.49
7
66
A
THR
0.39
0.33
0.45
1
87
A
VAL
0.44
0.56
0.40
9
88
A
LYS
0.50
0.25
0.55
4
89
A
LYS
0.57
0.25
0.45
9
90
A
ASP
0.50
0.32
0.64
10
91
A
THR
0.66
0.33
0.51
10
92
A
PRO
0.48
0.47
0.33
10
93
A
GLN
0.77
0.43
0.35
10
94
A
HIS
0.50
0.60
0.38
10
99
A
PHE
0.53
1.00
0.03
1
100
A
PHE
0.33
1.00
0.19
1
104
A
HIS
0.30
0.60
0.26
2
107
A
ARG
0.27
0.51
0.55
1
9
A
GLN
0.33
0.43
0.52
7
10
A
HIS
0.24
0.60
0.24
10
11
A
SER
0.57
0.36
0.33
6
12
A
ASP
0.40
0.32
0.48
5
13
A
ALA
0.40
0.38
0.46
10
14
A
CYS
0.99
0.64
0.30
10
15
A
LYS
0.45
0.25
0.48
10
16
A
ALA
0.30
0.38
0.60
10
17
A
GLU
0.58
0.33
0.59
10
19
A
GLY
0.75
0.41
0.50
10
20
A
VAL
0.56
0.56
0.31
10
21
A
SER
0.55
0.36
0.57
10
22
A
GLU
0.54
0.33
0.48
9
23
A
GLU
0.60
0.33
0.56
10
25
A
LEU
0.61
0.70
0.25
10
26
A
ASN
0.35
0.39
0.49
10
27
A
LYS
0.50
0.25
0.49
10
29
A
ARG
0.55
0.51
0.55
10
30
A
ASN
0.44
0.39
0.54
10
31
A
ARG
0.57
0.51
0.50
10
32
A
GLU
0.46
0.33
0.51
10
33
A
GLU
0.38
0.33
0.51
10
34
A
VAL
0.56
0.56
0.40
10
35
A
ASP
0.50
0.32
0.56
10
36
A
ASP
0.78
0.32
0.46
10
37
A
PRO
0.56
0.47
0.53
10
38
A
LYS
0.56
0.25
0.47
10
40
A
LYS
0.76
0.25
0.28
10
41
A
GLU
0.83
0.33
0.29
10
42
A
HIS
0.73
0.60
0.17
10
44
A
PHE
0.44
1.00
0.16
10
46
A
ILE
0.57
0.64
0.31
10
47
A
LEU
0.57
0.70
0.14
10
49
A
ARG
0.70
0.51
0.41
7
50
A
ALA
0.32
0.38
0.42
5
51
A
GLY
0.65
0.41
0.45
5
52
A
PHE
0.49
1.00
0.28
3
53
A
ILE
0.47
0.64
0.19
10
56
A
SER
0.37
0.36
0.59
1
57
A
GLY
0.81
0.41
0.40
1
58
A
GLU
0.40
0.33
0.51
1
59
A
PHE
0.49
1.00
0.36
6
60
A
GLN
0.54
0.43
0.38
1
63
A
HIS
0.37
0.60
0.50
1
87
A
VAL
0.44
0.56
0.42
6
88
A
LYS
0.50
0.25
0.58
8
89
A
LYS
0.57
0.25
0.49
6
90
A
ASP
0.50
0.32
0.60
8
91
A
THR
0.66
0.33
0.52
8
92
A
PRO
0.48
0.47
0.34
10
93
A
GLN
0.77
0.43
0.33
10
94
A
HIS
0.50
0.60
0.36
10
99
A
PHE
0.53
1.00
0.03
1
100
A
PHE
0.33
1.00
0.19
1
107
A
ARG
0.27
0.51
0.53
5